COMKAT:Compartment Model Kinetic Analysis/Imaging

COMKAT：房室模型动力学分析/成像

基本信息

批准号：
7028303
负责人：
RAYMOND F MUZIC
金额：
$ 27.42万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-04-01 至 2008-03-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Effective molecular imaging research depends on successful kinetic modeling of dynamic image data. The need for optimal experimental design and data analysis tools will grow as molecular imaging research expands. These techniques will be used in oncology (and other diseases) for diagnosis, staging, and monitoring response to therapy. Our overall objective is to fulfill currently unmet needs of quantitative analysis of image data. Our aims are to: 1) develop, 2) disseminate, and 3) support novel methods and new tools. The proposed methods and software will facilitate rapid, reliable quantification for in vivo characterization of molecular and cellular events. Integration of kinetic, molecular, and anatomic information will be key. We have already developed and implemented the core functionality for new methods in quantitative dynamic image analysis which we have named COMKAT: Compartment Model Kinetic Analysis Tool. COMKAT currently includes construction, simulation, and fitting user-specified models to kinetic data. We will expand its functionality and features by including co-registration, fusion and visualization of multi-modality data; region of interest specification and time-activity curve creation; generation of parametric images; optimal experiment design; and a library of examples. Moreover, we will develop new analysis and experiment design methods and assess their performance with simulations based on the developed software. Findings will be published to guide others in selecting analysis methods. In total, these developments serve as a necessary platform for future research and investigation. To maximize the value of this work, we will disseminate and support the software so that the cellular, molecular and general imaging communities may benefit from it. Specifically, we will expand the current web site from which COMKAT is distributed in source-code form. We will refine and expand the documentation; implement web-based version control for maintaining source code, documentation and web pages; implement web-based bug reporting and tracking; and create an online discussion forum. We will instruct people in use of the software; create an interactive, on-line course; develop new functionality in response to user requests; assist advanced modelers in expanding the software; and assist users in pre-study design of experiments and post-study analysis of data. We will establish an advisory panel composed of individuals experienced in quantitative analysis of images to guide and prioritize our development, dissemination and support processes. Many of these people will be associated with institutions that have NIH-supported In Vivo Cellular and Molecular Imaging Centers (ICMICs) or pre-ICMICs. NIH support to create quality analytical tools demanded by research is necessary since commercial product development is not economically feasible since the market for such software is small and specialized.

描述（由申请人提供）：有效的分子成像研究取决于动态图像数据的成功动力学建模。随着分子成像研究的扩展，对最佳实验设计和数据分析工具的需求将会增长。这些技术将用于肿瘤学（和其他疾病）的诊断、分期和监测治疗反应。我们的总体目标是满足当前未满足的图像数据定量分析需求。我们的目标是：1) 开发，2) 传播，3) 支持新方法和新工具。所提出的方法和软件将有助于快速、可靠地定量分子和细胞事件的体内表征。动力学、分子和解剖信息的整合将是关键。我们已经开发并实现了定量动态图像分析新方法的核心功能，我们将其命名为 COMKAT：房室模型动力学分析工具。 COMKAT 目前包括构建、模拟以及将用户指定的模型与动力学数据进行拟合。我们将通过多模态数据的共同注册、融合和可视化来扩展其功能和特性；感兴趣区域规范和时间活动曲线创建；参数化图像的生成；优化实验设计；和一个示例库。此外，我们将开发新的分析和实验设计方法，并根据开发的软件通过模拟评估其性能。研究结果将被发表，以指导其他人选择分析方法。总的来说，这些发展为未来的研究和调查提供了必要的平台。为了最大限度地发挥这项工作的价值，我们将传播和支持该软件，以便细胞、分子和一般成像社区可以从中受益。具体来说，我们将扩展当前以源代码形式分发 COMKAT 的网站。我们将完善和扩展文档；实施基于网络的版本控制，以维护源代码、文档和网页；实施基于网络的错误报告和跟踪；并创建一个在线讨论论坛。我们将指导人们使用该软件；创建交互式在线课程；根据用户请求开发新功能；协助高级建模师扩展软件；并协助用户进行研究前的实验设计和研究后的数据分析。我们将建立一个由具有图像定量分析经验的个人组成的顾问小组，以指导和优先考虑我们的开发、传播和支持流程。其中许多人将与拥有 NIH 支持的体内细胞和分子成像中心 (ICMIC) 或 pre-ICMIC 的机构有联系。 NIH 支持创建研究所需的高质量分析工具是必要的，因为商业产品开发在经济上不可行，因为此类软件的市场很小且专业化。