Type 2 Diabetes Risk Reduction for Minority Youth

降低少数族裔青少年 2 型糖尿病风险

• 批准号: 7082848
• 负责人: Alan M Delamater
• 金额: $ 22.19万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7082848
• 关键词: African American; Hispanic Americans; behavior therapy; behavioral /social science research tag; body physical activity; clinical research; clinical trials; diabetes education; diabetes risk; diet; disease /disorder prevention /control; family genetics; family structure /dynamics; focus groups; group counseling; health care service evaluation; health services research tag; human subject; human therapy evaluation; lifestyle; middle childhood (6-11); noninsulin dependent diabetes mellitus; obesity; racial /ethnic difference; social psychology; weight control

DESCRIPTION (provided by applicant): The incidence of type 2 diabetes has increased markedly among youth in recent years, particularly minority youth. This is likely due in part to the increased rate of obesity among ethnic minority children. Even in children, obesity apparently increases metabolic risk factors for type 2 diabetes, including elevated insulin and abnormal glucose tolerance, in addition to higher blood pressure. Given the fact that obesity in childhood is associated with high probability of continued obesity into adulthood, prevention of type 2 diabetes should begin by intervening with obesity in childhood. This study is designed to test the hypothesis that a lifestyle intervention for high-risk children will reduce their risk for later development of type 2 diabetes. High-risk children are considered to be those who are obese and who have a family history of type 2 diabetes. We will develop a family-based behavioral weight control program in a culturally appropriate manner, with multi-family group programming at children's schools and individually tailored programs at children's homes. Focus groups will be conducted to refine the intervention for cultural appropriateness and then the intervention will be pre-tested in additional focus groups. A small-scale pilot study will then be conducted in which 50 8-9 year-old minority children will be randomized to either receive the initial 12 months of the intervention or receive a control condition consisting of health risk feedback and educational materials. Primary outcomes are measures of obesity and metabolic risk, including estimates of insulin resistance. Secondary outcomes include measures of dietary intake and physical activity. The results of this study will contribute new information concerning risk factors for type 2 diabetes in children, and innovative methods to reduce type 2 diabetes risk in minority children at high risk for its development. These findings will provide the preliminary feasibility and efficacy data needed for the development and submission of a subsequent R18 application.

描述（由申请人提供）： 近年来，青少年尤其是少数民族青少年2型糖尿病的发病率明显上升。这可能部分是由于少数民族儿童肥胖率上升所致。即使在儿童中，肥胖也会明显增加 2 型糖尿病的代谢危险因素，除了血压升高之外，还包括胰岛素升高和糖耐量异常。鉴于儿童期肥胖与成年期持续肥胖的可能性很高有关，预防 2 型糖尿病应从干预儿童期肥胖开始。本研究旨在检验以下假设：对高危儿童进行生活方式干预将降低其日后患 2 型糖尿病的风险。高危儿童被认为是肥胖且有 2 型糖尿病家族史的儿童。我们将以适合文化的方式制定基于家庭的行为体重控制计划，在儿童学校开展多家庭团体计划，并在儿童家庭制定个性化计划。将进行焦点小组来完善干预措施以确保文化适当性，然后将在其他焦点小组中对干预措施进行预先测试。随后将进行一项小规模试点研究，其中 50 名 8-9 岁的少数民族儿童将被随机分配接受最初 12 个月的干预措施或接受由健康风险反馈和教育材料组成的控制条件。主要结果是肥胖和代谢风险的测量，包括胰岛素抵抗的估计。次要结果包括饮食摄入量和体力活动的测量。这项研究的结果将提供有关儿童 2 型糖尿病危险因素的新信息，以及降低高危少数民族儿童 2 型糖尿病风险的创新方法。这些发现将为后续 R18 申请的开发和提交提供所需的初步可行性和功效数据。