QUANTITATIVE ASSESSMENT OF THE SYNOVIAL VASCULARITY IN EARLY INFLAMMATORY ARTHRI

早期炎症性关节炎滑膜血管的定量评估

• 批准号: 7378413
• 负责人: LISA Ann MANDL
• 金额: $ 0.89万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378413
• 关键词: QUANTITATIVE; ASSESSMENT; SYNOVIAL; VASCULARITY; EARLY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A. Hypothesis: 1. MRA will effectively delineated neovascularization of the inflamed synovium. 2. MRA assessment of synovial vascularity will correlate with PDU measures of synovial blood flow. 3. MRA and PDU findings will correlate with previously validated MRI markers of RA disease activity. 4. MRA and PDU findings will correlate with serologic and clinical markers of inflammatory arthritis. B. Aims: 1. To ascertain if MRA is an effective method of imaging neovascularization in the inflamed RA synovium. 2. To correlate MRA measures of synovial vascularity with PDU measures of synovial blood flow. 3. To correlate MRA and PDU findings with validated MRI signs of joint inflammation. 4. To correlate MRA and PDU findings with serologic and clinical markers of inflammatory arthritis.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。 A.假设：1。MRA将有效地描绘出发炎的滑膜的新血管形成。 2。滑膜血管的MRA评估将与滑膜血流的PDU度量相关。 3。MRA和PDU的发现将与先前验证的RA疾病活性的MRI标记相关。 4。MRA和PDU的发现将与炎症性关节炎的血清学和临床标记相关。 B.目的：1。确定MRA是否是发炎的RA滑膜中新生血管化的有效方法。 2。将滑膜血管的MRA度量与PDU的滑动血流量度相关联。 3。将MRA和PDU的发现与已验证的关节炎症迹象相关。 4。将MRA和PDU的发现与炎症性关节炎的血清学和临床标记相关。