THE ROLE OF FORMATION OF SOLUBLE OLIGOMERS IN THE GROWTH OF AMYLOID FIBRILS

可溶性低聚物的形成在淀粉样原纤维生长中的作用

• 批准号: 7370444
• 负责人: SEBASTIAN DONIACH
• 金额: $ 0.02万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7370444
• 关键词: ROLE; FORMATION; SOLUBLE; OLIGOMERS; GROWTH

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Formation of amyloid fibrilar deposits occurs in a number of diseases and also appears to occur as a natural cause of certain epi-genetic changes of phenotype in yeast. Evidence that formation of amyloid seems to be generic to polypeptide chains suggests that the ability to identify specific positions in a protein sequence involved in oligomerization will allow a closer analysis of the underlying mechanism for amyloid formation in general, which is of interest in a large range of contexts, including major impacts on human health such as Alzheimer's and Parkinson's diseases.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。淀粉样蛋白纤维矿床的形成发生在多种疾病中，并且似乎是酵母中表型的某些表型变化的自然原因。淀粉样蛋白链的形成似乎是通用的证据表明，鉴定参与寡聚的蛋白质序列中的特定位置的能力将允许对一般淀粉样蛋白形成的潜在机制进行更深入的分析，这在整个环境中都具有对人类健康的影响，包括对人类健康的主要影响，包括对诸如Alzheimerers的主要影响。