Compositions for Prevention/Prophylactic Treatment of Poison Ivy Dermatitis

用于预防/预防性治疗毒藤皮炎的组合物

• 批准号: 7050909
• 负责人: MAHMOUD A ELSOHLY
• 金额: $ 10.01万
• 依托单位: ELSOHLY LABORATORIES, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-15 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7050909
• 关键词: contact dermatitis; guinea pigs; model; prevention

DESCRIPTION (provided by applicant): The long term objectives of this proposal are aimed at the development of new composition(s) to be used for the prophylactic treatment/prevention of poison ivy contact dermatitis in sensitive individuals. Poison ivy/poison oak and another related species poison sumac are the main cause of occupational hazards for outdoor workers in the United States. Most of the products on the market today are aimed at applying a chemical barrier prior to being exposed to these plants or directed toward symptomatic treatment of the dermatitis. The products proposed in this application will be directed towards treatment of individuals who have never been exposed to poison ivy and therefore inducing tolerance in these individuals (equivalent to immunization) and/or towards prophylactic treatment of already sensitive individuals, perhaps using a single injection prior to each season. The aims, therefore of this proposal will be to prepare (synthesize) different derivatives with enhanced physical and formulation characteristics, testing of these products (or at least 1 selected agent) in the guinea pig animal model for efficacy as a proof of concept. The results of this work will form the basis for a Phase II application directed toward optimization of formulation, dosage and route of administration as well as carrying out stability, pharmacokinetics and preclinical toxicology/developmental activities. This proposal addresses a major public health problem, namely contact allergic dermatitis and promises the development of an effective agent to address this problem.

描述（由申请人提供）：本提案的长期目标旨在开发用于预防性治疗/预防敏感个体毒藤接触性皮炎的新组合物。毒藤/毒橡树和另一种相关物种毒漆树是美国户外工人职业危害的主要原因。当今市场上的大多数产品旨在在接触这些植物之前施加化学屏障或针对皮炎进行对症治疗。本申请中提出的产品将针对从未接触过毒葛的个体的治疗，从而诱导这些个体的耐受性（相当于免疫）和/或针对已经敏感的个体的预防性治疗，可能在使用前进行单次注射。到每个季节。因此，本提案的目的是制备（合成）具有增强的物理和配方特性的不同衍生物，并在豚鼠动物模型中测试这些产品（或至少一种选定的药物）的功效，作为概念证明。这项工作的结果将构成 II 期应用的基础，旨在优化配方、剂量和给药途径，以及进行稳定性、药代动力学和临床前毒理学/开发活动。该提案解决了一个主要的公共卫生问题，即接触性过敏性皮炎，并承诺开发一种有效的药物来解决这个问题。