POLARIZED ION TRANSPORT DURING TIP GROWTH AND DIRECTED CELL MOTILITY

尖端生长和定向细胞运动期间的极化离子传输

• 批准号: 7357359
• 负责人: MARK A MESSERLI
• 金额: $ 2.45万
• 依托单位: MARINE BIOLOGICAL LABORATORY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7357359
• 关键词: POLARIZED; ION; TRANSPORT; DURING; TIP

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Tip growth and cell motility are highly directed forms of cellular motion. Tip growth is a form of polarized growth where exocytosis, leading to cell expansion, occurs at a single localized site, giving rise to long cylindrical or conical structures. Invasion by many pathogenic fungi and reproduction of higher plants is dependent on tip growth. Cell motility on the other hand involves migration of the entire cell. Many types of cells are able to migrate, including supporting glia of the nervous system, macrophages of the immune system and cancer cells. Both tip growth and cell motility can be directed by external cues to guide a population of cells that would normally grow/move in random directions. Our research has focused on the ionic control and signal transduction pathways that direct normal tip growth and cell motility and during the imposition of external guidance cues.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。尖端生长和细胞运动是细胞运动的高度定向形式。尖端生长是一种极化生长的一种形式，在一个局部位点，胞吞作用会导致细胞扩张，从而产生长的圆柱或圆锥结构。许多致病真菌的侵袭和较高植物的繁殖取决于尖端的生长。另一方面，细胞运动涉及整个细胞的迁移。许多类型的细胞能够迁移，包括支持神经系统的神经胶质，免疫系统和癌细胞的巨噬细胞。尖端生长和细胞运动性都可以由外部提示指导，以指导通常会在随机方向上生长/移动的细胞群。我们的研究集中在引导正常尖端生长和细胞运动的离子控制和信号转导途径上，并在强加外部引导提示期间。