CHARACTERIZATION OF EPILEPSY IN THE PEDIGREED BABOONS

纯种狒狒的癫痫特征

• 批准号: 7349779
• 负责人: akos szabo
• 金额: $ 0.23万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349779
• 关键词: CHARACTERIZATION; EPILEPSY; PEDIGREED; BABOONS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In humans and animals, there are many different classifications of epilepsy. The classification of seizures and epilepsy requires a detailed clinical history and correlation with interictal (between seizure) electroencephalography (EEG). In animals, to further characterize the seizure types, a careful observation of the seizures and the frequency is required. Spontaneous seizures have been reported in the pedigreed baboons at SFBR for over 15 years. The seizures have occurred in the absence of any overt neuropathologic, toxic or metabolic abnormalities, but the seizure types and frequency have not been well characterized. The seizures occur too infrequently to warrant continuous observation or monitoring. Different types of epilepsy, however, have distinctive EEG patterns. The information from these EEGs can be obtained and studied in an awake epileptic individual that is not having clinical seizure activity during the exam. Also intermittent light stimulation (photostimulation) can, in predisposed animals, induce clinical manifestations of epilepsy, seizures. A preliminary survey of the epileptic baboons using a combination of photostimulation and EEG recordings to characterize the type of epilepsy has demonstrated 3 distinct epileptic types. These animals represent a unique animal model for inherited epilepsy. From a clinical and genetic standpoint they will be useful to study epilepsy in humans and to test new drugs used to treat epilepsy.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。在人类和动物中，有许多不同的癫痫分类。癫痫发作和癫痫的分类需要详细的临床病史以及与止血（癫痫发作）脑电图（EEG）（EEG）的相关性。在动物中，为了进一步表征癫痫发作类型，需要仔细观察癫痫发作和频率。已在SFBR的弓形狒狒中据报道自发癫痫发作已有15年以上。癫痫发作发生在没有任何明显的神经病理，有毒或代谢异常的情况下，但是癫痫发作的类型和频率尚未得到很好的特征。这些癫痫发作很少发生，无法持续观察或监测。但是，不同类型的癫痫具有独特的脑电图模式。可以在考试期间没有临床癫痫发作活动的清醒癫痫发作中获得和研究这些脑电图的信息。在诱发的动物中，间歇性光刺激（光刺激）也可以诱导癫痫的临床表现，癫痫发作。使用光刺激和脑电图记录的组合来表征癫痫类型的癫痫狒狒的初步调查，显示出3种不同的癫痫类型。这些动物代表了遗传癫痫的独特动物模型。从临床和遗传的角度来看，它们对于研究人类的癫痫并测试用于治疗癫痫的新药将很有用。