BETA-CYCLODEXTRAN AS MUCOSAL MICROBICIDE TO PREVENT VAGINAL SIV TRANSMISSION

β-环糊精作为粘膜杀菌剂预防阴道 SIV 传播

• 批准号: 7349658
• 负责人: FABIEN X LU
• 金额: $ 15.67万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349658
• 关键词: BETA; CYCLODEXTRAN; MUCOSAL; MICROBICIDE; PREVENT

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To prevent heterosexually transmitted HIV, a mucosal anti-HIV microbicide is needed. B-cyclodextrin (BCD) is a cholesterol-sequestering agent that interferes with cell migration and budding of virus from lipid rafts. Mucosal application of BCD followed by vaginal cell-associated HIV-1 challenge in the mouse model is shown to block HIV transmission. BCD as a microbicide to block SIV vaginally transmission in the monkey model has never been tested. We thought the treatment with BCD will protect against repeated mucosal exposure of SIV and possibly result in mucosal and/or systemic immune responses.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。目的：为了预防异性传播艾滋病毒，需要一种粘膜抗艾滋病毒杀菌剂。 B-环糊精 (BCD) 是一种胆固醇螯合剂，可干扰细胞迁移和病毒从脂筏中出芽。在小鼠模型中，粘膜应用 BCD，然后进行阴道细胞相关的 HIV-1 攻击，结果显示可以阻止 HIV 传播。 BCD 作为一种杀微生物剂，可阻止 SIV 阴道传播，但从未在猴模型中进行过测试。 我们认为 BCD 治疗将防止粘膜反复暴露于 SIV，并可能导致粘膜和/或全身免疫反应。