Temperamental Low PE and HPA Reactivity in Preschoolers

学龄前儿童气质性低 PE 和 HPA 反应性

• 批准号: 7219307
• 负责人: LEA R DOUGHERTY
• 金额: $ 2.95万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-25 至 2007-09-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7219307
• 关键词: behavioral /social science research tag; biomarker; case history; child psychology; clinical research; cortisol; early experience; hormone metabolism; human subject; hypothalamic pituitary adrenal axis; mental health epidemiology; mood disorders; parent offspring interaction; personality; predoctoral investigator; preschool child (1-5); psychological stressor

DESCRIPTION (provided by applicant): Depression has consistently been associated with dysregulation of the HPA axis, the major physiological stress response system. The proposed research project will examine the relation between low positive emotionality (PE), a possible temperamental precursor to depression, and HPA functioning in preschoolers after a laboratory stress-inducing task and in their home environment. While several studies have examined the relation between other temperamental factors (e.g., behavioral inhibition) and HPA reactivity, no studies to date have examined the relation between low PE and HPA reactivity. Observations of children's temperament will be conducted in the laboratory, and parental history of psychopathology, parent-child relationship quality, as well as children's depressive symptoms, will be assessed. HPA functioning will be assessed using samples of salivary cortisol, a primary hormonal product of the HPA system. A basal salivary cortisol sample and 3 post-task samples will be collected, in addition to a morning and evening home sample. Mixed effects modeling will be used to predict preschoolers' HPA reactivity from their temperamental style, family history, and parent-child relationship quality. This study will also examine whether parental history of mood disorders and/or parent-child relationship quality moderate the relation between low PE and HPA reactivity.

描述（由申请人提供）： 抑郁症一直与 HPA 轴（主要的生理应激反应系统）失调有关。拟议的研究项目将研究低积极情绪（PE）（可能是抑郁症的气质前兆）与学龄前儿童在实验室诱发压力的任务后及其家庭环境中的 HPA 功能之间的关系。虽然有几项研究探讨了其他气质因素（例如行为抑制）与 HPA 反应性之间的关系，但迄今为止还没有研究探讨低 PE 与 HPA 反应性之间的关系。将在实验室对儿童的气质进行观察，并评估父母的精神病理学史、亲子关系质量以及儿童的抑郁症状。 HPA 功能将使用唾液皮质醇样本进行评估，唾液皮质醇是 HPA 系统的主要激素产物。除了早上和晚上的家庭样本外，还将收集基础唾液皮质醇样本和 3 个任务后样本。混合效应模型将用于根据学龄前儿童的气质风格、家族史和亲子关系质量来预测他们的 HPA 反应性。这项研究还将探讨父母的情绪障碍史和/或亲子关系质量是否调节低 PE 和 HPA 反应性之间的关系。