AMYGDALA VS HIPPOCAMPAL BDNF FUNCTION WITH MOLECULAR GENETIC TECHNIQUES

杏仁核与海马 BDNF 功能与分子遗传技术

• 批准号: 7349287
• 负责人: Kerry J Ressler
• 金额: $ 4.01万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-09 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349287
• 关键词: Lentivirus; amygdala; anxiety; fear; genes; genetically modified animals; laboratory mouse; molecular genetics

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal combines a novel lentivirus vector that expresses the Cre recombines with transgenic mice in which the BDNF gene has been flanked by LoxP sites (Floxed). These studies have allowed for the examination of anxiety and fear related symptoms in animals with hippocampal vs. amygdala deletions of the BDNF gene.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。该提案将表达 Cre 重组的新型慢病毒载体与 BDNF 基因侧翼为 LoxP 位点 (Floxed) 的转基因小鼠结合起​​来。这些研究允许检查海马与杏仁核 BDNF 基因缺失的动物的焦虑和恐惧相关症状。