FUNCTION OF THE GAMMAHV68 M2 ANTIGEN

GAMMAHV68 M2 抗原的功能

• 批准号: 7349211
• 负责人: SAMUEL H SPECK
• 金额: $ 4.01万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-09 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349211
• 关键词: antigens; infection; lead; lymphoma; model; neoplasm /cancer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Gammaherpesviruses are closely associated with the development of lymphoproliferative disease and lymphomas, as well as other cancers. The long-term goal of this research is to understand how gammaherpesviruses manipulate normal B or T cell development to persist within the lymphoid compartment of the infected host. Understanding the mechanisms used by gammaherpesviruses to persist in the infected host may lead to the development of strategies for interfering with chronic infection. The focus of the proposed studies on murine gammaherpesvirus 68 (gHV68; also referred to as MHV-68) represents an ongoing effort to develop a tractable small animal model for characterizing establishment and maintenance of gammaherpesvirus infection. The proposed studies focus on determining the function of one of the critical latency-associated antigens of gHV68, the M2 antigen).

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。伽马病毒与淋巴增生性疾病和淋巴瘤以及其他癌症的发展密切相关。这项研究的长期目标是了解伽马病毒如何操纵正常的B或T细胞发育以持续在受感染宿主的淋巴区室内。了解γ掌病毒在感染宿主中持续存在的机制可能会导致开发干扰慢性感染的策略。拟议的关于鼠伽马病毒68（GHV68;也称为MHV-68）的研究的重点是开发一种可拖动的小动物模型的持续努力，用于表征γ掌病毒感染的建立和维持。拟议的研究着重于确定GHV68（M2抗原）的关键潜伏相关抗原之一的功能。