Meningioma: Risk Factors and Quality of Life

脑膜瘤：危险因素和生活质量

• 批准号: 7393858
• 负责人: Joseph Leo Wiemels
• 金额: $ 40.79万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-26 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7393858
• 关键词: Accounting; Address; Age; Age-Years; Amendment; Androgen Receptor; Androgens; Area; Attention; Benign; Blood; Brain Neoplasms; Case-Control Studies; Categories; Cellular Phone; Cephalic; Clinical; Connecticut; County; Craniocerebral Trauma; DNA; DNA Repair; Data; Data Collection; Development; Diagnosis; Digit structure; Environmental Risk Factor; Epidemiologic Studies; Epidemiology; Estrogens; Ethnic Origin; Etiology; Exposure to; Family history of; Female; Genetic; Genetic Polymorphism; Geographic Locations; Geography; Histologic; Hormonal; Hormone Receptor; Hormone replacement therapy; Hormones; Housing; Individual; Intracranial Meningiomas; Intracranial Neoplasms; Ionizing radiation; Ki-67 Antigen; Lesion; Male Pattern Baldness; Malignant Neoplasms; Massachusetts; Methods; Neoplasms; Neurologic; North Carolina; Numbers; Oral Contraceptives; Outcome; Pathologic; Patients; Population; Prevalence; Process; Progesterone; Quality of life; Questionnaires; Radiation; Recording of previous events; Reporting; Risk; Risk Factors; San Francisco; Site; Specimen; Statutes and Laws; Study Subject; Targeted Research; Telephone; Testing; Texas; Time; Tumor Tissue; United States; Woman; base; cdc Genes; genetic risk factor; male; meningioma; neoplasm registry; neoplastic cell; receptor; reproductive; sex; tumor

= No large-scale study within the United States has examined any aspect of the epidemiology of intracranial meningiomas, a lesion which accounts for up to 25% of all primary intracranial neoplasms. We propose to conduct a population-based case/control study of meningioma within the states of Connecticut, Massachusetts, North Carolina, and Texas as well as the San Francisco Bay area under the mechanism of an integrated R01 (Note that identical applications are submitted for all five sites). Cases will be selected using rapid case ascertainment and will include all male and female individuals diagnosed with a histologically confirmed intra-cranial meningioma between the ages of 20 and 79 years from 7/1/2006 through 6/30/2010 in the above listed regions. Control subjects will be identified via random-digit dial methods and matched to the cases by sex, ethnicity, geographic location, and five-year age category. Study subjects will be administered a telephone questionnaire to collect information on the two primary categories of risk, exposure to ionizing radiation and hormones as well as additional risk factors such as family history of meningioma and other tumors, cell-phone utilization, and head trauma as well as questions on outcome and quality of life. Parraffin-embedded tumor tissue blocks will be obtained for case subjects to allow for 1) a uniform histological review, and 2) immunohistochemical testing for estrogen, progesterone, androgen and MIB-1 receptors. Blood or buccal specimens will be collected from all study subjects for testing of DNA polymorphisms in DNA repair and cell cycle genes. This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma.

=美国没有大规模研究检查了颅内脑膜瘤流行病学的任何方面，该病变占所有原发性颅内肿瘤的25％。我们建议在综合R01的机制下对康涅狄格州，马萨诸塞州，北卡罗来纳州和德克萨斯州以及旧金山湾地区的脑膜瘤进行基于人群的病例/对照研究（请注意，请注意所有五个五个地点的相同应用）。将使用快速案例确定的情况选择病例，其中包括所有被诊断出患有组织学确认的颅内脑膜瘤的男性和女性，从2006年7月1日至6/6/30/2010的年龄在20至79岁之间。控制受试者将通过随机数数字拨号方法来确定，并通过性别，种族，地理位置和五岁年龄类别与案例匹配。研究对象将进行电话问卷调查，以收集有关风险的两种类别，暴露于电离辐射和激素的信息，以及其他风险因素，例如脑膜瘤和其他肿瘤的家族史，细胞手机利用以及头部外伤以及有关生活和生活质量的问题。将获得帕拉弗蛋白包裹的肿瘤组织块，以便进行病例受试者，以进行1）均匀的组织学检查，以及2）雌激素，孕激素，雄激素和MIB-1受体的免疫组织化学测试。将从所有研究对象中收集血液或颊样本，以测试DNA修复和细胞周期基因中的DNA多态性。这项研究代表了检查脑膜瘤的环境和遗传危险因素的首次集中精力。