HIV Molecular Biology and Pathogenic Mechanisms of AIDS

HIV分子生物学与艾滋病发病机制

• 批准号: 7338798
• 负责人: George N. Pavlakis
• 金额: --
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7338798
• 关键词: HIV; Molecular; Biology; Pathogenic; Mechanisms

This project aims to understand the role and mechanism of function of HIV regulation in the virus life cycle and disease development; and to dissect the mechanisms of nucleocytoplasmic trafficking of macromolecules. The conclusions of this work are also applied towards the design of better vaccine approaches against AIDS. We have focused our studies in this period on the interactions of Rev and Vpr with cellular components; and on the further understanding of posttranscriptional regulation and nucleocytoplasmic export, which are important steps in the process of gene expression. Our results contribute significantly to the further understanding of the basic mechanisms of nucleocytoplasmic traffic of macromolecules. The understanding of the regulatory mechanisms of HIV gene expression has many important practical applications. We have applied this knowledge to the development of improved DNA vaccination approaches.

该项目旨在了解HIV调节功能在病毒生命周期和疾病发展中的作用和机制；并剖析大分子的核质运输机制。这项工作的结论还用于设计针对艾滋病的更好的疫苗方法。在此期间，我们将研究重点放在Rev和VPR与细胞成分的相互作用上。以及进一步理解转录后调节和核质的出口，这是基因表达过程中的重要步骤。我们的结果显着有助于进一步理解大分子核细胞质流量的基本机制。对HIV基因表达的调节机制的理解具有许多重要的实际应用。我们已经将这些知识应用于改进的DNA疫苗接种方法的发展。