Harvard/Brown Anxiety Research Project (HARP)

哈佛/布朗焦虑研究项目 (HARP)

• 批准号: 7173016
• 负责人: MARTIN B KELLER
• 金额: $ 65.72万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-04-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7173016
• 关键词: Address; Adult; African American; Age; Age of Onset; Aging; Agoraphobia; Anxiety; Anxiety Disorders; Benzodiazepines; Characteristics; Clinical; Comorbidity; Data; Data Analyses; Depressive disorder; Diagnostic; Disease; Doctor of Medicine; Dose; Elderly; Enrollment; Event; Gender; Generalized Anxiety Disorder; Guidelines; Hispanics; Impaired cognition; Impairment; Individual; Knowledge; Length; Life; Light; Location; Longevity; Major Depressive Disorder; Mediating; Mediator of activation protein; Medical; Mental Depression; Mental Health; Methods; Minority Groups; Modeling; Moods; Multicenter Studies; National Institute of Mental Health; Nature; Numbers; Outcome; Outpatients; Panic Disorder; Patients; Pattern; Pharmaceutical Preparations; Pharmacological Treatment; Physical Function; Population; Probability; Rate; Recording of previous events; Recovery; Recurrence; Research; Research Personnel; Research Project Grants; Risk; Role; Sampling; Score; Severities; Social Functioning; Social Phobia; Standards of Weights and Measures; Substance Use Disorder; Symptoms; Testing; Thinking; Time; Universities; aging population; base; disability; disease classification; ethnic minority population; falls; illness length; indexing; innovation; instrument; partial recovery; programs; prospective; psychosocial; stressor; theories; trait; two-dimensional

DESCRIPTION (provided by applicant): We propose to continue the Harvard/Brown Anxiety Research Project (HARP), a unique, naturalistic, prospective, multicenter study of 711 subjects with anxiety disorders, who were enrolled when seeking treatment at mental health outpatient settings, for an additional 5 years of f/u. This will enable us to obtain a minimum of 15 years of f/u on subjects and to incorporate new assessments and data analysis methods in order to address important unanswered questions and develop a more comprehensive picture of the longitudinal course and outcome of common anxiety disorders: panic disorder with and without agoraphobia, generalized anxiety disorder, and social phobia. Enrollment of African-American and Hispanic subjects with anxiety disorders during the first three years of this proposal will enable us to obtain a representative sample and to examine the clinical characteristics, longitudinal course, and course mediators, in unstudied ethnic minority populations. Our specific aims are to 1) examine patterns, predictors and psychosocial outcomes of anxiety course; 2) examine factors associated with the clinical course of anxiety disorders in an aging population; 3) describe somatic and psychosocial treatment received and investigate the mediating effect of somatic treatment on course; 4) examine the course of anxiety disorders in African-Americans and Hispanics; and 5) examine the utility of dimensional approaches in characterizing and understanding the nature and course of the anxiety disorders and comorbid depressive disorders. Subjects will be evaluated at annual intervals with instruments that obtain detailed information on symptom status and severity, diagnostic status, treatment received, psychosocial functioning, stressful life events, and other domains. We have added a new assessment that will allow us to examine the effects of anxiety disorders on medical disorders and disability. We have also incorporated new data analysis methods to take maximum advantage of the new data. HARP is unique in its large number of subjects, comprehensiveness of assessment, and length of prospective f/u. This proposal will obtain meaningful new knowledge about anxiety disorders as described in a substantial revision of previous aims and hypotheses using new findings from HARP and other investigators during the past 4 years. Continuation of HARP should shed new light on clinically and theoretically important, innovative questions about a group of common and impairing disorders that have not been adequately addressed by previous research, particularly within African-Americans and Hispanics.

描述（由申请人提供）：我们建议继续进行哈佛/棕色焦虑研究项目（HARP），这是一项独特，自然，前瞻性，多中心研究，对711名患有焦虑症的受试者，他们在心理健康门诊患者环境中寻求治疗时已入学，又有5年的f/u。这将使我们能够在受试者上获得至少15年的f/u，并结合新的评估和数据分析方法，以解决重要的未解决问题，并为常见焦虑症的纵向过程和结果进行更全面的了解：患有和不具有性欲恐惧症的恐慌症的恐慌症，普遍的焦虑症和社会恐惧症。在本提案的前三年中，非裔美国人和西班牙裔受试者的入学率将使我们能够获得代表性的样本，并在未经研究的少数民族中研究临床特征，纵向课程和课程调解人。我们的具体目的是1）检查焦虑过程的模式，预测因素和社会心理结果； 2）检查与人口老龄化的焦虑症临床过程相关的因素； 3）描述接受的体细胞和社会心理治疗，并研究了体细胞治疗对当前的中介作用； 4）检查非裔美国人和西班牙裔焦虑症的进程； 5）检查维度方法在表征和理解焦虑症和合并性抑郁症的性质和过程中的实用性。将以每年的时间间隔评估受试者，以获取有关症状状况和严重程度，诊断状态，接受治疗，社会心理功能，压力性生活事件和其他领域的详细信息。我们添加了一种新的评估，将使我们能够检查焦虑症对医疗疾病和残疾的影响。我们还合并了新的数据分析方法，以最大程度地利用新数据。 HARP在大量受试者，评估的全面性和预期F/U的长度上是独一无二的。该提案将在过去4年中使用HARP和其他研究人员的新发现对先前目标和假设进行实质性修订中所描述的有关焦虑症的有意义的新知识。竖琴的延续应该对临床和理论上重要的，创新的问题进行新的启示，以了解一群常见和损害的疾病，这些疾病尚未得到以前的研究，特别是在非裔美国人和西班牙裔中。