Prenatal Ethanol Exposure and Epigenetic Regulation of Immune Function in Newborn

产前乙醇暴露与新生儿免疫功能的表观遗传调节

• 批准号: 7467623
• 负责人: THOMAS W BOYCE
• 金额: $ 12.06万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7467623
• 关键词: Adjuvant; Adjuvant Arthritis; Adrenal Glands; Adverse effects; Age; Alcohol consumption; Alcohols; Animal Model; Animals; Argipressin; Arthritis; Aversive Stimulus; Behavioral; Brain; CRH gene; Cell Count; Chromatin Structure; Chronic; Clinical; Condition; Corticosterone; Corticotropin; Corticotropin-Releasing Hormone; Cytokine Receptors; DNA Methylation; Data; Development; Disease; Endocrine; Endocrine system; Environment; Epigenetic Process; Estradiol; Ethanol; Etiology; Exhibits; Exposure to; Female; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetus; Freund' s Adjuvant; Gene Expression; Gene Expression Profile; Gene Expression Regulation; Genes; Glucocorticoids; Goals; Hippocampus (Brain); Hormone Receptor; Hormones; Human; Hypothalamic structure; Immune; Immune system; Immunity; Inflammatory; Inflammatory Response; Interleukin-10; Interleukin-6; Life; Literature; Longevity; Lymphoid; Measurement; Measures; Mediating; Messenger RNA; Methylation; Microarray Analysis; Mineralocorticoids; Modeling; Modification; Molecular Profiling; Monitor; Neurosecretory Systems; Newborn Infant; Operative Surgical Procedures; Organ; Organism; Pathway interactions; Peripheral; Pharmaceutical Preparations; Phase; Physiological; Pituitary Gland; Plasma; Pregnancy; Rattus; Recovery; Regulation; Resolution; Rest; Rheumatism; Role; Route; Saline; Serotonin; Spleen; Staging; Stress; T-Lymphocyte; Testing; Thymus Gland; Time; Weight; Weight Gain; alcohol effect; alcohol exposure; base; concept; cytokine; day; environmental stressor; experience; feeding; fetal; fetal programming; immune function; insight; lymph nodes; male; novel; postnatal; prenatal; prenatal exposure; programs; pup; response; salicylhydroxamic acid; stressor

Project 2 (Project Leader: Joanne Weinberg) will test the hypotheses that prenatal ethanol exposure in fetal rats alters neuroimmunological functions through fetal programming of the hypothalamic-pituitaryadrenocortical (HPA) axis and that the cellular mechanism by which such i.mmunological effects occur is epigenetic modification of HPA-related gene expression.

项目 2（项目负责人：Joanne Weinberg）将测试胎儿产前乙醇暴露的假设 大鼠通过下丘脑-垂体肾上腺皮质的胎儿编程改变神经免疫功能 （HPA）轴，并且发生这种免疫效应的细胞机制是 HPA 相关基因表达的表观遗传修饰。