Wireless Implantable Intraocular Pressure Sensor System

无线植入式眼压传感器系统

基本信息

批准号：
7215301
负责人：
Lawrence Wan
金额：
$ 41.91万
依托单位：
BIOMEMS, LLC
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-05-01 至 2009-09-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7215301
关键词：
Acceleration Acids Address Affect Animals Artificial cardiac pacemaker Atmospheric Pressure Biocompatible Biocompatible Coated Materials Biocompatible Materials Bite Blindness Budgets Calibration Cannulas Cardiac Cataract Characteristics Charge Chemicals Clinical Clinical Data Code Communication Communities Compatible Computer Simulation Computer software Consumption Contact Lenses Critiques Custom Data Dental Implants Deposition Depth Development Devices Diabetic Retinopathy Diagnosis Dimensions Disease Disease Management Drainage procedure Drug Delivery Systems Electronics Encapsulated Engineering Ensure Equipment Evaluation Eye Eye diseases Failure Fatty acid glycerol esters Frequencies Funding Gases Glaucoma Glean Goals Grant Hand Healthcare Heart Atrium Heating Hour Human Implant Individual Industry Insulin Infusion Systems International Intraocular lens implant device Intraocular pressure test Invasive Lead Left Letters Life Life Style Link Location Longevity Macular degeneration Measurement Measures Medical Membrane Methodology Methods Miniaturization Mission Modeling Modification Monitor National Eye Institute Noise Numbers Operative Surgical Procedures Orthopedics Output Outsourcing Pain Patients Pattern Performance Permeability Personal Satisfaction Pharmaceutical Preparations Pharmacotherapy Phase Physicians Physiologic Intraocular Pressure Placement Play Poly C Polymers Population Positioning Attribute Process Proteins Purpose Range Reading Relative (related person)Research Research Methodology Resistance Resolution Resources Respiratory Diaphragm Retina Risk Risk Factors Role Sclera Signal Transduction Silicon Sleep Small Business Funding Mechanisms Small Business Innovation Research Grant Source Standards of Weights and Measures Stream Surface Surgeon Syringes System Techniques Technology Teflon Temperature Testing Therapeutic Time Tissues Titrations United States Food and Drug Administration Vacuum Validation Walking Water Wireless Technology attenuation base biocompatible polymer biomaterial compatibility body system bone commercial application concept day density design digital driving force evaluation/testing implantable device implantation improved information gathering manufacturing process medical specialties meter miniaturize monomer nerve supply particle parylene parylene C performance tests pressure prevent prototype remediation research and development response sensor simulation size software development success technological innovation three-dimensional modeling tonometry tool transmission process vapor vibration voltage

项目摘要

DESCRIPTION (provided by applicant): This research will assess the technical feasibility of developing a new and unique miniature ophthalmic intraocular pressure (IOP) sensor, to be retrofitted into the cannula of a conventional Glaucoma Drainage Device (GDD) and surgically implanted under the sclera for the purpose of continuous measurement and transmission of these IOP readings to a remote receiver. Current technology does not allow for real-time, continuous monitoring of IOP (24/7, diurnal and nocturnal readings). The long-term objective of this project is to enable physicians to study, diagnose and more clearly understand the response mechanism relating to IOP that can lead to more effective development and titration of glaucoma medications or other timely therapeutic options. Elevated and fluctuating IOP over a 24/7 period is an independent and proven risk factor for eye damage in the short term and glaucoma progressions in the long term, which if left unchecked or unmanaged could lead to blindness. This Phase II research is dedicated to developing technologies that assist physicians to more effectively treat the glaucoma patient. This is inline with the mission of the National Eye Institute. Under Phase II, specific aims include system microminiaturization, packaging and biocompatibility. Research and development will specifically involve designing, fabricating, and integrating various MEMS and ASIC chips into a unitized singular micro scale chip to perform a number of systems activities (i.e. power transfer [RF-ID], chip interrogation, IOP data capture and storage, wireless data transfer, remediation, resolution, etc.) involving methods researched and determined in the successful portion of Phase I. These sequential methods include design input, product development, product integration (MEMS sensor, ASIC & biocompatible materials) and product validation and testing. In conclusion, with this telemetric IOP sensing technology, physicians will be able to measure the effects that medications and life-style factors have on the IOP of their patients in a real- time and continuous model.

描述（由申请人提供）：本研究将评估开发一种新型独特的微型眼科眼内压（IOP）传感器的技术可行性，该传感器将被改装到传统青光眼引流装置（GDD）的插管中并通过手术植入巩膜下用于连续测量这些 IOP 读数并将其传输到远程接收器。当前技术不允许实时、连续监测 IOP（24/7、白天和夜间读数）。该项目的长期目标是使医生能够研究、诊断并更清楚地了解与 IOP 相关的反应机制，从而更有效地开发和调整青光眼药物或其他及时的治疗方案。 24/7 期间眼压升高且波动是短期眼损伤和长期青光眼进展的独立且经证实的风险因素，如果不加以控制或不加以控制，可能会导致失明。这项二期研究致力于开发帮助医生更有效地治疗青光眼患者的技术。这符合国家眼科研究所的使命。第二阶段的具体目标包括系统微型化、封装和生物相容性。研究和开发将具体涉及设计、制造各种 MEMS 和 ASIC 芯片并将其集成到一个单元化的单一微型芯片中，以执行许多系统活动（即功率传输 [RF-ID]、芯片询问、IOP 数据捕获和存储、无线数据传输、修复、解决等）涉及在第一阶段成功部分研究和确定的方法。这些顺序方法包括设计输入、产品开发、产品集成（MEMS 传感器、ASIC 和生物相容性材料）以及产品验证和测试。总之，利用这种遥测眼压传感技术，医生将能够以实时、连续的模型测量药物和生活方式因素对患者眼压的影响。