FAMILIAL IGA NEPHROPATHY: GENETIC AND FAMILIAL STUDIES

家族性 IGA 肾病：遗传和家族研究

• 批准号: 7603178
• 负责人: BRUCE A JULIAN
• 金额: $ 0.69万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603178
• 关键词: Biochemical Genetics; Biostatistics Core; Blood; Blood Pressure; Cell Line; Clinical; Computer Retrieval of Information on Scientific Projects Database; Creatinine; Development; Disease; Enrollment; Foundations; Funding; Future; Genetic; Grant; Height; Immunoglobulin A; Institution; Kentucky; Kidney Diseases; Measures; Outpatients; Participant; Pathogenesis; Physicians; Physicians' Offices; Proteins; Research; Research Personnel; Resources; Sampling; Serum; Source; Tennessee; United States National Institutes of Health; Urinalysis; Urine; Venous; Visit; Weight; base; programs; urinary

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will provide clinical resources for the Clinical and Biostatistics Core of a multicenter Program Project that is comprised of three projects investigating the genetic and biochemical aspects of IgA nephropathy. The program Project will enroll about 1515 participants, but only about 1000 at UAB. About 550 of the UAB participants will be seen in the GCRC for their single physician visit, while about 450 UAB participants will be seen during field trips at physician offices outside of Birmingham. The other 515 participants will be seen by investigators in Tennessee and Kentucky. The Specific Aims of this study are: 1. Measure blood pressure, height, and weight for participants seen in the UAB GCRC. 2. Collect venous blood and urine samples during the one outpatient visit for the participants seen at UAB GCRC. 3. Perform urinalysis, serum creatinine concentration, and urinary protein and creatinine concentrations for all 1515 participants using blood and urine samples either collected in the UAB GCRC or by UAB investigators during field trips, or sent from participating outside centers. 4. Establish EBV-transofrmed cell lines for some participants, to be selected by the investigators based upon their potential to contribute to the genetic studies of familial IgA nephropathy. The findings from this Program Project will substantially increase the understanding of the pathogenesis of a common renal disease and may be the foundation for future development of a disease-specific therapy.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究将为一个多中心计划项目的临床和生物统计学核心提供临床资源，该项目由研究IGA肾病的遗传和生化方面的三个项目组成。该计划项目将招收约1515名参与者，但在UAB只有1000个参与者。大约有550名UAB参与者将在GCRC中看到他们的一次医师访问，而在伯明翰郊外的医师办公室的实地考察期间，将看到约450名UAB参与者。田纳西州和肯塔基州的调查人员将看到其他515名参与者。 这项研究的具体目的是： 1。测量UAB GCRC中参与者的血压，身高和体重。 2.在UAB GCRC的参与者进行一次门诊期间，收集静脉血液和尿液样本。 3.使用在UAB GCRC中收集的血液和尿液样本或在实地考察期间收集的血液和尿液样本，或者在实地考察中收集的血液和尿液样本，或者从参与外部的中心进行尿液分析，血清肌酐浓度以及尿蛋白浓度和肌酐浓度。 4。为某些参与者建立EBV传输细胞系，由研究人员根据其潜力有助于家族性IGA肾病的遗传研究来选择。 该计划项目的发现将大大增加对常见肾脏疾病发病机理的理解，并可能是未来疾病特异性疗法发展的基础。