EATRIGHT FOR LIFE

终身饮食

• 批准号: 7603241
• 负责人: Jamy D Ard
• 金额: $ 1.52万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603241
• 关键词: Adoption; African American; Behavior; Behavior Therapy; Blood Glucose; Blood Pressure; Blood specimen; Body Weight; Body Weight decreased; Cardiovascular system; Caucasians; Caucasoid Race; Cereals; Cheese; Cholesterol; Classification; Collection; Communities; Computer Retrieval of Information on Scientific Projects Database; County; Cross-Over Studies; Data Collection; Data Quality; Development; Dietary Intervention; Discipline of Nursing; Economics; Effectiveness; Effectiveness of Interventions; Employee; Fatty acid glycerol esters; Fiber; Food; Funding; Glucose; Grant; Height; Hypertension; Individual; Informatics; Ingestion; Institution; Insulin; Intervention; Laboratories; Lead; Life; Life Style; Lipids; Measurement; Measures; Meat; Metabolic; Metabolic Diseases; Methodology; Non-Insulin-Dependent Diabetes Mellitus; Numbers; Obesity; Outcome; Patients; Pattern; Physiology; Pilot Projects; Plague; Research; Research Design; Research Personnel; Research Project Grants; Resources; Risk; Sampling; Serum; Source; Testing; Time; United States; United States National Institutes of Health; Week; Weight; Weight maintenance regimen; base; cardiovascular risk factor; concept; disorder risk; energy density; follow-up; fruits and vegetables; health disparity; improved; information gathering; prevent; programs; sample collection; sugar; tool; waist circumference; weight loss intervention

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The number of obese individuals in the United States is increasing. For African Americans, the increase in obesity has been disproportionate. This is very concerning, particularly given the preventable health disparities that plague the African American community. Fortunately, we have tools that could be used to lead to healthier lifestyles. Historically, the effectiveness of these interventions has not been optimal for African Americans. For example, typical weight loss interventions routinely show less weight loss for African Americans compared to Caucasians. Weight loss improves cholesterol, blood pressure, risk of hypertension, blood glucose, and can prevent the development of type 2 diabetes. Therefore, many of the benefits that African Americans could receive from weight loss are not realized. Our research team believes that the ineffectiveness of weight loss interventions in African Americans can be overcome by developing tailored approaches that consider the cultural framework of African Americans. Utilizing a systematic approach to understand how African American cultural perspectives influence the adoption of new dietary behaviors related to body weight is hypothesized to lead to more effective weight loss interventions. Using a period of formative assessment to gather information regarding the key cultural variables, we propose to develop and implement a culturally appropriate behavioral intervention for weight control based on the EatRight dietary pattern. EatRight is a 12-week lifestyle-oriented weight control program based on the concept of "time-calorie displacement," which emphasizes the ingestion of large quantities of high-bulk, low-energy-density foods (primarily vegetables, fruits, high-fiber grains, and cereals) and moderation in high-energy-density foods (meats, cheeses, sugars, and fats). We will use qualitative methodologies to inform our development of the tailored dietary intervention. Following the formative assessment, using a cross-over study design, the intervention will be delivered in a group of African American employees of the Jefferson County Committee for Economic Opportunity. The primary outcome is change in weight, with secondary measures of markers of cardiovascular risk including blood pressure, lipids, glucose, and insulin. The successful completion of this project will lead to a widely usable dietary intervention with demonstrated effectiveness in African Americans. To complete our study, we will require additional nursing resources for patient measurements and specimen collection and lab analysis. The nursing resources will be used for collection of blood for glucose, insulin, lipids, and measurement of height, weight, waist circumference, and blood pressure in a community setting. Measures of glucose, insulin, and lipids are used to estimate cardiovascular and metabolic disease risk. The physiology and metabolic core laboratory will be utilized for analysis of the blood specimens. We will request analysis of 40 serum samples for glucose, insulin, and lipids at 3 points over the duration of the study (at baseline, 6 and 12 month follow-up). The informatics core will be used to assist in data collection and management. The biostatistical core will be helpful in providing analysis support when testing the primary and secondary hypotheses. With the resources provided by the GCRC, we are confident that this pilot study can be used to generate quality data and outcomes that can be parlayed into larger research projects.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 美国肥胖个体的数量正在增加。对于非裔美国人来说，肥胖的增加是不成比例的。 这非常令人担忧，特别是考虑到困扰非裔美国人社区的可预防健康差异。幸运的是，我们有可以用来导致更健康生活方式的工具。 从历史上看，这些干预措施的有效性并不是非裔美国人的最佳选择。 例如，与高加索人相比，典型的体重减轻干预措施通常显示非洲裔美国人的体重减轻更少。 体重减轻可改善胆固醇，血压，高血压风险，血糖，并可以防止2型糖尿病的发展。 因此，没有实现非洲裔美国人可以从减肥中获得的许多好处。 我们的研究小组认为，可以通过开发考虑非裔美国人文化框架的量身定制方法来克服非裔美国人减肥干预措施的无效性。 假设采用系统的方法来了解非裔美国人的文化观点如何影响采用与体重相关的新饮食行为，从而导致更有效的减肥干预措施。 使用一段时期的形成性评估来收集有关关键文化变量的信息，我们建议开发和实施基于Eatright饮食模式的文化上适当的行为干预，以控制体重。 EaTright是一个基于“时间卡路里流离失所”的概念，是一个为期12周的面向生活方式的体重控制计划，该计划强调摄入大量的高蛋白，低能密度的食物（主要是蔬菜，水果，高纤维，高纤维，高纤维，谷物和谷物）以及高含量的食物（肉类和奶酪）（肉类，奶酪，奶酪，奶酪，奶酪，奶油，奶油，奶油，奶油味）。 我们将使用定性方法来告知我们量身定制的饮食干预措施的发展。 经过形成性评估，使用跨界研究设计，该干预措施将在杰斐逊县经济机会委员会的非裔美国人雇员中进行。 主要结果是体重的变化，其次要措施是心血管风险的标志物，包括血压，脂质，葡萄糖和胰岛素。 该项目的成功完成将导致广泛使用的饮食干预措施，并在非洲裔美国人中表现出效率。 为了完成我们的研究，我们将需要更多的护理资源来进行患者测量以及标本收集和实验室分析。护理资源将用于收集血糖，胰岛素，脂质以及在社区环境中的身高，体重，腰围和血压的测量。葡萄糖，胰岛素和脂质的措施用于估计心血管和代谢疾病风险。生理和代谢核心实验室将用于分析血液标本。我们将在研究期间（基线，6个月和12个月的随访时）对40种血清，胰岛素和脂质的血清样品进行分析。信息学核心将用于协助数据收集和管理。在测试主要和次要假设时，生物统计核心将有助于提供分析支持。借助GCRC提供的资源，我们有信心该试点研究可用于生成质量数据和结果，这些数据和结果可以被划入较大的研究项目中。