INSULIN SENSITIVITY, HEMDYNAMICS AND ENDOTHELIAL FUNCTION IN WOMAN

女性胰岛素敏感性、血流动力学和内皮功能

• 批准号: 7603430
• 负责人: DARCY R CARR
• 金额: $ 0.16万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603430
• 关键词: Address; Cardiac Output; Computer Retrieval of Information on Scientific Projects Database; Cross-Over Studies; Cross-Sectional Studies; Disease; Double-Blind Method; Dyslipidemias; Functional disorder; Funding; Grant; High Cardiac Output; Institution; Insulin; Insulin Resistance; Link; Measurement; Metabolic syndrome; Obesity; Postpartum Period; Postpartum Women; Pre-Eclampsia; Pregnancy; Recording of previous events; Research; Research Design; Research Personnel; Resources; Source; Thinking; United States National Institutes of Health; Vasodilation; Woman; insulin sensitivity; mortality; neonatal morbidity; randomized placebo controlled trial; rosiglitazone

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pre-eclampsia, a hypertensive disorder unique to pregnancy, is leading cause of maternal and neonatal morbidity and mortality. Endothelial dysfunction is a central feature in the pathophysiology of pre-eclampsia and mechanisms that have been suggested to contribute to the endothelial dysfunction include hyperinsulinenmia, dyslipidemia, and high cardiac output. Insulin resistance and high cardiac output persist postpartum, suggesting that these women have an underlying disorder. It is unknown whether there is persistence of other features commonly associated with the metabolic syndrome and whether these features are linked and contribute to endothelial dysfunction. Thus, the specific aims of this proposal are: 1) Evaluate postpartum women with a history of pre-eclampsia for features of the insulin resistance and the metabolic syndrome that are thought to contribute to endothelial dysfunction, and 2) Explore the relationships between insulin resistance and these identified features by evaluating for improvement in these abnormalities after insulin resistance is ameliorated with an insulin sensitizing agent. A cross-sectional study, designed to examine specific aim 1, will address the hypothesis that postpartum women with a history of pre-eclampsia are insulin resistant and have features of the metabolic syndrome (central adiposity, dyslipidemia, elevated cardiac output, and decreased endothelial dependent vasodilation) as compared to women without a history of pre-eclampsia. A double-blind, placebo-controlled randomized study will address the second hypothesis using an insulin sensitizing agent, rosiglitazone, in a 6 month cross-over study with measurements at baseline, 6 months, and 12 months.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 子痫前是一种妊娠特有的高血压疾病，是孕产妇和新生儿发病率和死亡率的主要原因。 内皮功能障碍是前宾夕法尼亚前病理生理学的主要特征和已建议导致内皮功能障碍的机制的机制，包括多胰岛素蛋白元，血脂异常和高心脏输出。 胰岛素抵抗和高心输出量持续存在，这表明这些女性患有潜在的疾病。 尚不清楚是否存在通常与代谢综合征相关的其他特征，以及这些特征是否链接并导致内皮功能障碍。 因此，该提案的具体目的是：1）评估具有胰岛素抵抗的特征和代谢综合征的特征的产后女性，这些妇女被认为有助于胰岛素抵抗和这些胰岛素的胰岛素内胰岛素的胰岛素内疾病之间的胰岛素内疾病之间的关系，这些特征被认为有助于促进内皮功能障碍，2） 代理人。 一项旨在检查特定目标1的横断面研究将解决以下假设：具有前启示蛋白史的产后女性具有胰岛素耐药性，并且具有代谢综合征的特征（中心脂肪，血脂异常，心脏输出升高，心脏输出升高，与没有依赖于依恋的女性相比）。 一项双盲，安慰剂对照的随机研究将在一个为期6个月的跨界研究中使用胰岛素敏化剂Rosiglitazone来解决第二个假设，并在基线，6个月和12个月时进行了测量。