GLUCOCORTICOID REGULATION OF MEMORY PERFORMANCE IN AGING HUMANS

糖皮质激素对老年人记忆力的调节

• 批准号: 7603305
• 负责人: JOHN W. NEWCOMER
• 金额: $ 0.34万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603305
• 关键词: Aging; Animals; Calcium Channel Blockers; Computer Retrieval of Information on Scientific Projects Database; Condition; Dose; Experimental Designs; Funding; Gene Expression; Glucocorticoids; Grant; Hippocampus (Brain); Human; Hydrocortisone; Individual; Institution; Knowledge; Memory; Memory impairment; Performance; Physiology; Prevention; Regulation; Research; Research Personnel; Resources; Risk; Source; Stress; Testing; Time; United States National Institutes of Health; age related; base; brain metabolism; neuropsychiatry; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Glucocorticoids (GCs) are know to regulate brain metabolism, physiology and gene expression, particularly in the hippocampus, as well as memory function in whole animals. Various GCs, including the endogenous human GC cortisol, can dose-and time-dependently decrease human memory in a reversible manner. These results are relevant to both iatrogenic GC exposure and stress-related neuropsychiatric conditions. In addition recent studies in aging humans suggest that age-related increases in cortisol levels are associated with progressice age-related memory declines. Based on these associations, this application proposes to now test the direct effect of GC exposure on older humans using a controlled experimental design so that the "dose" threshold for significant effects in younger and older humans can be defined. This knowledge is critical to the identification of individuals at risk for memory impairment and ultimately to treatment considerations for the prevention of this effect (e.g., GC receptor antagonists or calcium channel blockers).

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 众所周知，糖皮质激素（GC）可以调节大脑代谢、生理和基因表达，特别是在海马体中，以及整个动物的记忆功能。各种GC，包括内源性人GC皮质醇，可以以可逆的方式剂量和时间依赖性地降低人类记忆。这些结果与医源性GC暴露和压力相关的神经精神疾病相关。此外，最近对老年人的研究表明，与年龄相关的皮质醇水平增加与与年龄相关的记忆力逐渐下降有关。基于这些关联，本申请建议现在使用受控实验设计来测试GC暴露对老年人的直接影响，以便可以定义对年轻人和老年人产生显着影响的“剂量”阈值。这些知识对于识别有记忆障碍风险的个体以及最终预防这种影响的治疗考虑（例如 GC 受体拮抗剂或钙通道阻滞剂）至关重要。