Contraception & Metabolic Changes in HIV-positive Women

避孕

• 批准号: 7226305
• 负责人: Julie A Womack
• 金额: $ 4.16万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7226305
• 关键词: Acquired Immunodeficiency Syndrome; Adolescent; Adverse effects; Affect; African American; Age; Age of Onset; Area; Cardiovascular Diseases; Cause of Death; Child; Chronic Disease; Cohort Studies; Color; Combined Oral Contraceptives; Contraceptive Agents; Contraceptive Usage; Contraceptive methods; Data Analyses; Death Rate; Diabetes Mellitus; Diagnosis; Epidemic; Ethnic group; Family; Fatty acid glycerol esters; Fellowship; Female; General Population; Glucose; Glucose Intolerance; HIV; Heart Diseases; Highly Active Antiretroviral Therapy; Hispanics; Hormonal; Hormones; Hypertension; Hypertriglyceridemia; Individual; Insulin Resistance; International; Life; Lipids; Literature; Metabolic; Metabolic Diseases; Metabolic syndrome; Minority; Names; National Health and Nutrition Examination Survey; Nature; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Opportunistic Infections; Outcome; Palliative Care; Population; Pregnancy; Pregnancy Rate; Premenopause; Prevalence; Progestins; Provider; Rate; Research; Research Methodology; Research Personnel; Risk; Risk Factors; Sterilization for infection control; Stroke; Time; Training; United States; Virus Diseases; Woman; Youth; age group; antiretroviral therapy; birth control; cohort; design; experience; high density lipoprotein-1; impaired glucose tolerance; lipid metabolism; male; men; pill; racial and ethnic

DESCRIPTION (provided by applicant): Management of the side effects of antiretroviral therapy (ART) has become a primary focus in the treatment of human immunodeficiency virus (HlV)-infected individuals. Among the most pervasive of these side effects are the metabolic complications. As more women are infected with HIV, and as HIV/AIDS becomes a chronic disease rather than a lethal diagnosis, more of these women will be looking for ways to have families and space pregnancies, rather than to terminate their ability to reproduce. However, despite research in the general literature that points to significant metabolic dysregulation with contraceptive use, especially in areas that overlap with the side effects seen in HIV and its treatment, no research has yet examined whether or not contraceptive hormone use contributes to HIV-infected women's risk for metabolic complications. A secondary data analysis of the Women's Interagency HIV Study (WIHS) cohort is proposed as an initial step towards investigating this problem. The training plan is designed to provide the informational background and research experience necessary to allow the trainee to carry out the research plan. The sponsors will contribute their expertise in HIV/AIDS, metabolic dysregulation, and research methodology.

描述（由申请人提供）：抗逆转录病毒疗法（ART）的副作用的管理已成为治疗人类免疫缺陷病毒（HLV）感染个体的主要重点。这些副作用最普遍的是代谢并发症。随着越来越多的女性感染艾滋病毒，艾滋病毒/艾滋病成为一种慢性疾病而不是致命的诊断，更多的女性将寻找有家庭和太空怀孕的方法，而不是终止其繁殖能力。然而，尽管一般文献研究表明，避孕药使用避孕及其副作用与HIV及其治疗重叠的领域有关，但尚无研究检查避孕激素的使用是否有助于艾滋病毒感染的女性对代谢复杂性的风险。提出对妇女间艾滋病毒研究（WIHS）队列的二级数据分析，作为研究此问题的第一步。培训计划旨在提供必要的信息背景和研究经验，以允许学员执行研究计划。赞助商将在艾滋病毒/艾滋病，代谢失调和研究方法方面贡献他们的专业知识。