Simulation of Optimal Surgical Insertion of Pediatric Ventricular Assist Device

儿科心室辅助装置最佳手术插入的模拟

• 批准号: 7332510
• 负责人: ARIELLE DRUMMOND
• 金额: $ 4.46万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7332510
• 关键词: 3-Dimensional; Abdomen; Abdominal Cavity; Address; Age-Years; Anastomosis - action; Anatomic Models; Anatomy; Animals; Area; Biocompatible; Biocompatible Materials; Birth; Blood; Blood Circulation; Blood Clot; Blood Vessels; Blood coagulation; Caliber; Cannulas; Cannulations; Cardiopulmonary Bypass; Cardiovascular system; Chest; Child; Childhood; Chronic; Clinical Trials; Collection; Computer software; Congenital Heart Defects; Data Set; Defect; Development; Devices; Dissection; Doctor of Philosophy; Exposure to; Failure; Generations; Heart Diseases; Heart Septal Defects; Hemorrhage; Hemostatic function; Hypoplastic Left Heart Syndrome; Image; Imagery; In Vitro; Infection; Invasive; Lateral; Length; Libraries; Liquid substance; Magnetism; Measurement; Modeling; Modification; Names; Operative Surgical Procedures; Patients; Placement; Population; Procedures; Protocols documentation; Pump; Range; Rate; Research; Research Project Grants; Risk; Risk Factors; Solid; Stress; Students; Surface; System; Techniques; Technology; Testing; Tetralogy of Fallot; Thoracotomy; Thrombosis; Transfusion; Transposition of Great Vessels; Trauma; Ventricular; Ventricular septum; Work; analog; anesthesia complication; ascending aorta; base; biomaterial compatibility; design; design and construction; digital; digital models; hemodynamics; improved; instrument; member; physical model; prototype; reconstruction; simulation; size; three-dimensional modeling; tissue trauma; tool; ventricular assist device

DESCRIPTION (provided by applicant): Young children who require circulatory support typically undergo a highly invasive procedure involving great loss of blood, multiple transfusions, and exposure to large biomaterial surface area. This project aims to address these risk factors by developing a rapidly-deployable anastomosis system in conjunction with an implantable ventricular assist device (VAD). It is intended for chronic support (6 months) of a unique and high-risk population of children between 2.5kg and 15kg (patients from birth to two years of age). The system will be comprised of a means for pre-surgical planning, a rapid anastomosis connector, and a minimally-invasive surgical insertion tool. The system will accommodate various anatomic anomalies, and the typical configuration will entail cannulation from the ventricular apex to the ascending aorta. Preoperative CT images will be reconstructed to provide a three-dimensional solid model of the thorax and vasculature. These models will be used in the development of simulations for the placement of the VAD and cannulae in patients. An anastomosis device and insertion tool is being designed to enable rapid dissection, cannulation, and hemostasis, ideally deployable though a lateral thoracotomy. The advantages of this cannulation system will be to obviate cardiopulmonary bypass and attendant complications of bleeding, thrombosis, infection and complications associated with transfusion.

描述（由申请人提供）：需要循环系统支持的幼儿通常会接受高度侵入性的程序，涉及血液丧失，多种输血以及暴露于大型生物材料表面积。该项目的目的是通过与可植入的心室辅助装置（VAD）结合开发快速部署的吻合系统来解决这些危险因素。它旨在用于2.5公斤至15公斤（从出生到两岁的患者）的独特和高危儿童的慢性支持（6个月）。该系统将由手术前计划，快速吻合连接器和微创手术插入工具组成。该系统将适应各种解剖异常，典型的配置将需要从心室顶点到上升主动脉进行插管。术前CT图像将被重建，以提供胸腔和脉管系统的三维固体模型。这些模型将用于开发模拟，以在患者中放置VAD和插管。正在设计一种吻合装置和插入工具，以使快速解剖，插管和止血，理想地通过侧胸切开术可部署。该插管系统的优点将是消除出血，血栓形成，感染和与输血相关的并发症的心肺旁路并发症。