Social & Language Deficits in Autism-Biology & Treament

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• 批准号: 7278579
• 负责人: MARIAN D SIGMAN
• 金额: $ 145.21万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-13 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7278579
• 关键词: Autistic Disorder; Basic Science; Behavioral; Behavioral Genetics; Biological; Biology; Brain; Characteristics; Child; Cognitive; Communities; Development; Early identification; Educational process of instructing; Effectiveness of Interventions; Etiology; Family member; Friends; Future; Genetic; Genetic Predisposition to Disease; Genotype; Goals; Image; Infant; Intervention; Language; Language Disorders; Neural Pathways; Pharmacogenetics; Phenotype; Research; Research Personnel; Resources; Siblings; Structure; Symptoms; Techniques; Testing; Time; Treatment Efficacy; administrative database; base; design; disorder risk; endophenotype; improved; member; outreach; peer; proband; programs; social

The goal of the UCLA Center for Autism Research and Treatment (CART) is to conduct basic research on genetics, brain structure and function, and behavioral development as well as experimental interventions in order to understand the biological bases and possible environmental remedies for core deficits in autism. The central theme of the UCLA CART is on the elucidation of the etiology of social, communicative, and language deficits in autism, and the second theme is on the design and testing of experimental interventions. The specific aims of the CART research are to 1) Identify the abilities and characteristics, both behavioral and genetic, which differentiate the infant siblings of children with autism from siblings of developmentally delayed and typically developing siblings and predict the later manifestations of autistic symptoms; 2) Determine the neural pathways used by children with autism and typically developing children in understanding prosody and language; 3) Implement and compare the effects of intervention projects aimed at ameliorating behavioral disturbances and improving interactions with family members, peers, and friends; and 4) Define the genetic contributions to autism by studying component cognitive and behavioral endophenotypes and performing specific genotype - phenotype correlations, thereby, laying the groundwork for future pharmacogenetic studies. Besides providing resources to the projects, each Core will have a unique educational component. The Administrative-Database Core will contain a Pilot Program; the Imaging Core will develop means for teaching their techniques to a wider group of autism researchers; and the Assessment and Outreach Core will organize an educational program for Center members as well as for the community groups with whom we are cooperating.

UCLA自闭症研究与治疗中心（CART）的目标是对遗传学，大脑结构和功能以及行为发展以及实验干预措施进行基础研究，以了解自闭症核心缺陷的生物学基础和可能的环境补救措施。 UCLA推车的中心主题是阐明自闭症中社会，交流和语言缺陷的病因，第二个主题是在实验干预措施的设计和测试上。购物车研究的具体目的是1）确定行为和遗传的能力和特征，这些能力和特征将自闭症儿童的婴儿兄弟姐妹与发育中的兄弟姐妹区分开 延迟且通常发展兄弟姐妹，并预测自闭症症状的后期表现； 2）确定自闭症儿童使用的神经通路，通常会在理解韵律和语言方面发展儿童； 3）实施和比较旨在改善行为干扰并改善与家人，同伴和朋友的互动的干预项目的影响； 4）通过研究组件认知和行为内表型并进行特定的基因型 - 表型相关性来定义对自闭症的遗传贡献，从而为未来的药物遗传学研究奠定了基础。除了为项目提供资源外，每个核心还将具有独特的 教育部分。行政数据库核心将包含一个试点计划；成像核心将开发用于向更广泛的自闭症研究人员传授技术的方法。评估和外展核心将为中心成员以及与我们合作的社区团体组织一个教育计划。

项目成果

The peer relationships of girls with ASD at school: comparison to boys and girls with and without ASD.

• DOI: 10.1111/jcpp.12242
• 发表时间: 2014-11
• 期刊: Journal of child psychology and psychiatry, and allied disciplines
• 作者: Dean M;Kasari C;Shih W;Frankel F;Whitney R;Landa R;Lord C;Orlich F;King B;Harwood R
• 通讯作者: Harwood R

Social network analysis of children with autism spectrum disorder: Predictors of fragmentation and connectivity in elementary school classrooms.

• DOI: 10.1177/1362361315603568
• 发表时间: 2016-08
• 期刊: Autism : the international journal of research and practice
• 作者: Anderson A;Locke J;Kretzmann M;Kasari C;AIR-B Network
• 通讯作者: AIR-B Network

Social networks and friendships at school: comparing children with and without ASD.

• DOI: 10.1007/s10803-010-1076-x
• 发表时间: 2011-05
• 期刊: JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
• 影响因子: 3.9
• 作者: Kasari, Connie;Locke, Jill;Gulsrud, Amanda;Rotheram-Fuller, Erin
• 通讯作者: Rotheram-Fuller, Erin

Mothers' reports of play dates and observation of school playground behavior of children having high-functioning autism spectrum disorders.

• DOI: 10.1111/j.1469-7610.2010.02318.x
• 发表时间: 2011-05
• 期刊: Journal of child psychology and psychiatry, and allied disciplines
• 作者: Frankel FD;Gorospe CM;Chang YC;Sugar CA
• 通讯作者: Sugar CA

How early do parent concerns predict later autism diagnosis?

• DOI: 10.1097/dbp.0b013e3181ba0fcf
• 发表时间: 2009-10
• 期刊: Journal of developmental and behavioral pediatrics : JDBP
• 作者: Ozonoff S;Young GS;Steinfeld MB;Hill MM;Cook I;Hutman T;Macari S;Rogers SJ;Sigman M
• 通讯作者: Sigman M