Structure-Based Antisickling Peptides that Inhibit Hb S Polymerization

抑制 Hb S 聚合的基于结构的抗镰化肽

• 批准号: 7538867
• 负责人: KAZUHIKO ADACHI
• 金额: $ 24.97万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7538867
• 关键词: Address; Affect; Amino Acids; Bacteriophages; Binding; Cell Nucleus; Characteristics; Chemicals; Computers; Crystal Formation; Development; Disease; Drug Design; Drug Receptors; Electrons; Electrostatics; Engineering; Entropy; Equilibrium; Erythrocytes; Fiber; Gel; Generations; Globin; Goals; Helix (Snails); Hemoglobin; Hydrogen Bonding; Hydrophobic Interactions; Kinetics; Knowledge; Lateral; Methodology; Microscopic; Movement; Mutagenesis; Mutation; Nature; Peptide Mapping; Peptides; Phage Display; Pharmacologic Substance; Play; Polymers; Positioning Attribute; Process; Property; Rate; Role; Sickle Cell Anemia; Side; Site; Solubility; Specificity; Structure; Technology; Testing; Therapeutic Agents; Thermodynamics; Three-Dimensional Image; Time; Variant; Viral Vector; X-Ray Crystallography; base; concept; design; ear helix; gene therapy; hemoglobin C-Harlem; hemoglobin polymer; improved; in vitro Assay; magnetic beads; methyl group; monomer; novel therapeutics; polymerization; protein protein interaction; protein structure; sickling