CLINICAL CORE

临床核心

基本信息

批准号：
7560789
负责人：
ERIC HOLLANDER
金额：
$ 24.92万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-05-01 至 2009-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7560789
关键词：
Adolescent Affect Autistic Disorder Autoimmune Process Biological Birth History Blood specimen Centers of Research Excellence Child Clinical Clinical Research Clinical Trials Cognitive Communities Community Health Education Comorbidity Condition DNA Data Data Collection Data Files Development Developmental Disabilities Diagnosis Diagnostic Disease Eligibility Determination Enrollment Evaluation Family Family member Female Functional Imaging Funding Future Genetic Genetic Research Genetic Screening Genetic Services Goals Gold Health system Image Individual Interview Laboratories Leadership Measures Medical Medical History Neurobiology New York Patients Pharmacological Treatment Population Procedures Psychopharmacology Recruitment Activity Registries Research Research Project Grants Resources Sampling Screening procedure Site Source Standards of Weights and Measures Symptoms Universities autism spectrum disorder clinical research site cohort computerized data management family genetics follower of religion Jewish human subject lymphoblastoid cell line medical schools minority subjects neuropsychological north shore long island programs research facility sample collection statistics

项目摘要

The primary objective of the Clinical Core (Core B) will be to provide a well-characterized cohort of subjects with autism and autism spectrum disorders and non-autistic control subjects for enrollment in GNYARCE research projects and collaborative endeavors. Core B will acquire comprehensive clinical and laboratory data through diagnostic evaluation and assessment of comorbidity, cognitive, developmental, and adaptive assessment, medical history and screening, and genetic sample collection from autistic and autism spectrum subjects as well as family members and control/comparison subjects, as appropriate. It will collect a common set of assessment data and measure target core symptom domains and associated features and comorbid conditions to better define the cohort. The Core will provide baseline evaluation to assess diagnostic eligibility and cognitive ability, perform a functional analysis, and characterize core symptomatology for inclusion in Projects I, II, and III. To accomplish its goals, Core B will utilize three clinical research sites and a genetic research site: the Seaver Autism Research Center at the Mount Sinai School of Medicine, the Cody Center for Autism and Developmental Disabilities at the State University of New York at Stony Brook, the Center for Autism in the North Shore-Long Island Jewish Health System, and the Family Genetic Studies Program at Mount Sinai.

临床核心（核心B）的主要目的是提供具有自闭症和自闭症谱系障碍的受试者的良好特征组，以及非自动谱系障碍和非自动控制受试者，以入学GNYARCE研究项目和协作工作。核心B将通过诊断和评估合并症，认知，发育和自适应评估，病史和筛查以及自闭症和自闭症谱系受试者以及家庭成员以及控制/比较受试者的遗传样本收集，通过诊断评估和评估来获取全面的临床和实验室数据。它将收集一组共同的评估数据，并衡量目标核心症状域和相关特征以及合并条件以更好地定义同类。核心将提供基线评估，以评估诊断资格和认知能力，执行功能分析，并表征核心症状，以纳入项目I，II和III。为了实现其目标，Core B将利用三个临床研究网站和一个遗传研究网站：西奈山医学院的Seaver自闭症研究中心，纽约州立大学Stony Brook州立大学自闭症与发育障碍中心，Stony Brook的自闭症和发育障碍中心，北岸犹太人犹太人卫生系统的自闭症中心以及Sinai Mount Sinai Mount Sinai sinai。