CORE 3: INFRASTRUCTURE

核心 3：基础设施

• 批准号: 7622848
• 负责人: Joel S. Bader
• 金额: $ 32.74万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7622848
• 关键词: Biomedical Engineering; Computational Biology; Computer Retrieval of Information on Scientific Projects Database; Core Facility; Faculty; Funding; Grant; Individual; Institution; Metabolic; Pathway interactions; Proteins; Research; Research Infrastructure; Research Personnel; Resources; Services; Side; Signal Pathway; Source; Triciribine Phosphate; United States National Institutes of Health; design; member; network models; technology development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Department of Biomedical Engineering and member of the HiT Center. The HiT Center was expressly designed to support and facilitate large, interdisciplinary and technology development projects such as that proposed for this TCNP. The HiT Center consists of several faculty research groups side by side with highly advanced core facilities; thus considerable infrastructure to support the proposed project already exists. We propose to add to this infrastructure a computational biology core designed to meet the specific computational needs of the investigators in the TCNP. In the computational biology support core, Dr. Bader, together with his colleague in Biomedical Engineering, Dr. Andre Levchenko, will provide computational support services for all members of this TCNP. Both of these individuals are experts in the computational biology of protein interaction networks and pathways. Dr. Levchenko has special expertise in dynamic networks and modeling quantitative changes in metabolic and signaling pathways

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 生物医学工程系和热门中心成员。热门中心的设计明确设计旨在支持和促进大型，跨学科和技术开发项目，例如为该TCNP提出的。热门中心由几个教师研究小组与高级高级核心设施并排组成。因此，支持拟议项目的大量基础设施已经存在。我们建议将基础架构添加到旨在满足TCNP研究人员的特定计算需求的计算生物学核心。 在计算生物学支持核心中，Bader博士以及他的生物医学工程学同事Andre Levchenko博士将为该TCNP的所有成员提供计算支持服务。这两个人都是蛋白质相互作用网络和途径的计算生物学专家。 Levchenko博士在动态网络方面具有特殊专业知识，并建模代谢和信号通路的定量变化