Excitatory Controls of Eating in Eating Disorders

饮食失调中饮食的兴奋性控制

• 批准号: 7243446
• 负责人: DIANE A KLEIN
• 金额: $ 17.67万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7243446
• 关键词: Alcohol or Other Drugs use; Andro-Diane; Animal Feed; Animal Model; Anorexia Nervosa; Area; Arousal; Award; Basic Science; Behavioral; Binge Eating; Body mass index; Bulimia; Calories; Characteristics; Clinical Research; Condition; Cues; Disease; Eating; Eating Behavior; Eating Disorders; Exposure to; Feedback; Feeding behaviors; Flavoring; Food; Goals; Individual; Investigation; Laboratory Animals; Measurement; Measures; Mental disorders; Mentored Patient-Oriented Research Career Development Award; Mentorship; Methodology; Modeling; Neurosciences; Obesity; Oral; Patient Self-Report; Patients; Personal Satisfaction; Persons; Population; Principal Investigator; Procedures; Property; Protocols documentation; Purpose; Rate; Reporting; Research; Research Personnel; Research Training; Sensory; Solutions; Stimulus; Stomach; Substance abuse problem; Sucrose; Techniques; Text; Training; Translating; Translational Research; Weight; Woman; Women' s Group; Work; base; desire; experience; feeding; insight; programs; psychologic; purge; response; sham feeding; size; skills; stem; sweet taste perception

DESCRIPTION (provided by applicant): Bulimia nervosa (BN) is a serious and prevalent psychiatric disorder characterized by frequent uncontrolled eating episodes known as binges, in which an inordinately large amount of food is consumed. The purpose of this Mentored Patient-Oriented Research Career Development Award (MPORCDA) is to develop and execute a program of translational research that will investigate the behavioral abnormalities associated with excessive excitation of eating in this population, in order to ultimately identify the underlying mechanisms that sustain binge eating. The fields of animal feeding basic science research and substance abuse research will provide conceptual and methodological approaches for this line of investigation. Specific aims are to (1) adapt a model of sham feeding for use in persons with BN to demonstrate that enhanced responsiveness to sweet taste is associated with prolonged meals in the absence of post-oral effects and (2) develop a model of cue reactivity in persons with BN to demonstrate that exposure to a binge food cue is associated with increased urge to binge, and with actual binge eating. Specific aim (3) will extend these studies to women with Anorexia Nervosa (AN) and obesity, both with and without binge eating. The rationale and methodologies of each of these paradigms and their relevance to eating disorders are detailed in the proposal. Under the continued strong mentorship of Dr. B. Timothy Walsh (for clinical research training and expertise in eating disorders), Dr. Richard Foltin (for substance abuse research training), Dr. Norcross Geary (for training in the behavioral neuroscience of eating), and collaborators expert in the fields of animal feeding research and substance abuse, this MPORCDA will provide the principal investigator with the skills and further experience to integrate and translate the advances of the fields of behavioral neuroscience of feeding and substance abuse, to the study of eating disorders. The long-term goal of this award is for the candidate to become an expert and independent researcher in translational research in eating disorders.

描述（由申请人提供）：神经性贪食症（BN）是一种严重且普遍的精神病障碍，其特征是频繁的不受控制的饮食发作，称为Binges，其中消耗了大量的食物。这项受过指导的以患者为导向的研究职业发展奖（MPORCDA）的目的是制定和执行一项转化研究计划，该计划将调查与该人群过度激发饮食相关的行为异常，以最终确定可持续暴饮暴食的基本机制。动物喂养基础科学研究和药物滥用研究的领域将为这一研究提供概念和方法论方法。具体的目的是（1）调整一种假喂食模型，以在BN的患者中使用，以证明对甜味的反应性增强与不存在后效应的情况下长时间的饭菜有关，以及（2）在BN的人中发展出一种提示的模型，以证明暴露于与狂热食品相关的狂热和与实际味觉相关的狂热，并与实际的味觉相关。具体目的（3）将把这些研究扩展到神经性厌食症（AN）和肥胖症的女性，无论有没有暴饮暴食。该提案中详细介绍了每种范式的理由和方法论及其与饮食失调的相关性。在B.蒂莫西·沃尔什（B.饮食障碍研究的行为神经科学领域。该奖项的长期目标是候选人成为饮食失调转化研究的专家和独立研究人员。