Individual Differences in Sensitization to Amphetamine

对安非他明敏感度的个体差异

• 批准号: 7207996
• 负责人: DAVID M DIETZ
• 金额: $ 3.56万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7207996
• 关键词: Affect; Amphetamines; Behavior; Behavioral; Chronic; Chronic stress; Corticotropin-Releasing Hormone Receptors; Development; Dopamine; Dopamine D1 Receptor; Dose; Drug Addiction; Exhibits; Gene Proteins; Genes; Glucocorticoid Receptor; Glucocorticoids; Hormone Receptor; Individual; Individual Differences; Mediating; Messenger RNA; Modeling; Molecular; Neurobiology; Pharmaceutical Preparations; Phenotype; Property; Proteins; Psychosocial Stress; Rattus; Self Administration; Stress; Testing; Thinking; Tyrosine 3-Monooxygenase; Work; addiction; base; behavioral sensitization; dopamine transporter; drug of abuse; hypothalamic-pituitary-adrenal axis; psychostimulant; social; social stress

DESCRIPTION (provided by applicant): The overall aim of this work is to investigate the neurobiological basis of behavioral sensitization to amphetamine in the context of individual differences. We aim to understand the interplay between psychosocial stress and the development of behavioral sensitization to amphetamine in the context of individual differences. Behavioral sensitization is relevant to drug addiction as it is thought that the neurobiological changes that may underlie sensitization to psychostimulants may be the same, or at least overlap with, changes that may cause addiction to drugs of abuse. Furthermore, it is thought that stress and glucocorticoids in particular, may mediate some aspects of behavioral sensitization as well as drug taking behaviors. We will examine how gene and protein changes in the dopamine and stress circuitry may mediate the propensity of some individuals to become sensitized to psychostimulants. We will use this model of individual differences to help understand how and why some individuals are more prone to the effects of drugs of abuse.

描述（由申请人提供）： 这项工作的总体目标是研究个体差异背景下对安非他明行为敏感的神经生物学基础。我们的目标是了解个体差异背景下心理社会压力与安非他明行为敏感性发展之间的相互作用。行为过敏与药物成瘾相关，因为人们认为，可能导致对精神兴奋剂过敏的神经生物学变化可能与可能导致滥用药物成瘾的变化相同，或至少重叠。此外，人们认为压力和特别是糖皮质激素可能介导行为敏化以及吸毒行为的某些方面。我们将研究多巴胺和压力回路中的基因和蛋白质变化如何调节某些个体对精神兴奋剂敏感的倾向。我们将使用这种个体差异模型来帮助理解某些人如何以及为何更容易受到滥用药物的影响。