Opioid Modulation of Cue-Triggered 'Wanting' in Amygdala

阿片类药物对杏仁核中提示触发的“想要”的调节

• 批准号: 7298601
• 负责人: Stephen Vincent Mahler
• 金额: $ 3.26万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2009-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7298601
• 关键词: Affect; Agonist; Amygdaloid structure; Anxiety; Area; Behavior; Behavioral; Cues; Data; Dependency; Diffusion; Disease; Dorsal; Dose; Drug Addiction; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Environment; Exploratory Behavior; FOS gene; Feeding behaviors; Fellowship; Female; Food; Human; Incentives; Individual; Individual Differences; Infusion procedures; Injection of therapeutic agent; Learning; Light; Measures; Mediation; Microinjections; Motivation; Names; Nature; Neurons; Obesity; Opioid; Opioid Receptor; Pharmaceutical Preparations; Predisposition; Process; Rattus; Rewards; Risk; Role; Site; Specificity; Standards of Weights and Measures; Sucrose; Testing; Thinking; Training; Variant; addiction; approach behavior; behavior test; day; drug relapse; immunoreactivity; mu opioid receptors; novel; preference; relating to nervous system; research study; response; reward processing; trait

DESCRIPTION (provided by applicant): The aim of this proposal is to explore the involvement of mu opioid receptors (MORs) in the amygdala on the attribution of incentive motivation to natural reward-associated cues. Preliminary results indicate that infusion of the specific MOR agonist DAMGO (0.1 mu g) into the amygdala increases feeding behavior in female rats. Additionally, we found that DAMGO administered prior to each of the first six days of autoshaping training increases approaches to one of two reward associated cues, depending on individual differences between rats in 'preferred' cue. In the proposed experiments, we first seek to determine the dose dependency and MOR mediation of these enhancements in CS+ approach behavior. Second, we seek to determine whether observed appetitive effects of CeA DAMGO are specific to the amygdala. Third, we seek to determine whether individual differences in pre-autoshaping anxiety, exploratory, and reward sensitivity are related to individual differences observed in autoshaping. This project is relevant to understanding the neural substrates of, and role of individual differences in human appetitive disorders such as addiction and obesity.

描述（由申请人提供）：该提案的目的是探索MU阿片受体（MOR）在杏仁核中的参与，以激励动机归因于自然奖励相关线索。初步结果表明，将特定的MOR激动剂DAMGO（0.1 MU G）输注到杏仁核中会增加雌性大鼠的喂养行为。此外，我们发现，在自动训练训练的前六天之前，DAMGO对两个相关提示之一的方法提高了方法，这取决于“首选”提示中大鼠之间的个体差异。在拟议的实验中，我们首先寻求确定CS+进近行为中这些增强的剂量依赖性和MOR介导。其次，我们试图确定观察到的CEA DAMGO的食欲是否针对杏仁核。第三，我们试图确定焦虑，探索性和奖励敏感性中的个体差异是否与在自动修饰中观察到的个体差异有关。该项目与理解人类食用性疾病（如成瘾和肥胖症）中的神经底物以及个体差异的作用有关。