Opioid Modulation of Cue-Triggered 'Wanting' in Amygdala

阿片类药物对杏仁核中提示触发的“想要”的调节

• 批准号: 7298601
• 负责人: Stephen Vincent Mahler
• 金额: $ 3.26万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2009-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7298601
• 关键词: Affect; Agonist; Amygdaloid structure; Anxiety; Area; Behavior; Behavioral; Cues; Data; Dependency; Diffusion; Disease; Dorsal; Dose; Drug Addiction; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Environment; Exploratory Behavior; FOS gene; Feeding behaviors; Fellowship; Female; Food; Human; Incentives; Individual; Individual Differences; Infusion procedures; Injection of therapeutic agent; Learning; Light; Measures; Mediation; Microinjections; Motivation; Names; Nature; Neurons; Obesity; Opioid; Opioid Receptor; Pharmaceutical Preparations; Predisposition; Process; Rattus; Rewards; Risk; Role; Site; Specificity; Standards of Weights and Measures; Sucrose; Testing; Thinking; Training; Variant; addiction; approach behavior; behavior test; day; drug relapse; immunoreactivity; mu opioid receptors; novel; preference; relating to nervous system; research study; response; reward processing; trait

DESCRIPTION (provided by applicant): The aim of this proposal is to explore the involvement of mu opioid receptors (MORs) in the amygdala on the attribution of incentive motivation to natural reward-associated cues. Preliminary results indicate that infusion of the specific MOR agonist DAMGO (0.1 mu g) into the amygdala increases feeding behavior in female rats. Additionally, we found that DAMGO administered prior to each of the first six days of autoshaping training increases approaches to one of two reward associated cues, depending on individual differences between rats in 'preferred' cue. In the proposed experiments, we first seek to determine the dose dependency and MOR mediation of these enhancements in CS+ approach behavior. Second, we seek to determine whether observed appetitive effects of CeA DAMGO are specific to the amygdala. Third, we seek to determine whether individual differences in pre-autoshaping anxiety, exploratory, and reward sensitivity are related to individual differences observed in autoshaping. This project is relevant to understanding the neural substrates of, and role of individual differences in human appetitive disorders such as addiction and obesity.

描述（由申请人提供）：本提案的目的是探索杏仁核中 mu 阿片受体（MOR）对激励动机归因于自然奖励相关线索的参与。初步结果表明，将特异性 MOR 激动剂 DAMGO (0.1 μg) 注入杏仁核可增加雌性大鼠的摄食行为。此外，我们发现在自塑训练前六天的每一天之前给予 DAMGO 可以增加对两种奖励相关线索之一的接近，具体取决于大鼠在“首选”线索方面的个体差异。在拟议的实验中，我们首先试图确定 CS+ 方法行为中这些增强的剂量依赖性和 MOR 介导。其次，我们试图确定观察到的 CeA DAMGO 食欲效应是否是杏仁核特有的。第三，我们试图确定自我塑造前焦虑、​​探索和奖励敏感性的个体差异是否与自我塑造中观察到的个体差异相关。该项目与了解成瘾和肥胖等人类食欲障碍的神经基质和个体差异的作用有关。