The Role of Tonic Neural Responses in Auditory Pitch Perception in Awake Rat A1

强直神经反应在清醒大鼠 A1 听觉感知中的作用

• 批准号: 7275562
• 负责人: Andrew Michael Sloan
• 金额: $ 3.3万
• 依托单位: UNIVERSITY OF OKLAHOMA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-22 至 2009-01-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7275562
• 关键词: Acute; Anesthetics; Animals; Auditory; Auditory area; Auditory pitch; Behavior; Behavioral; Behavioral Paradigm; Brain; Brain Injuries; Cereals; Characteristics; Childhood; Classification; Code; Condition; Discrimination; Dyslexia; Electrodes; Esthesia; Fire - disasters; Frequencies; High Prevalence; Human; Implant; Individual; Investigation; Knowledge; Language Development; Language Disorders; Learning Disorders; Masks; Mediation; Neurologic; Neurons; Patients; Pattern; Perception; Performance; Physiologic pulse; Pitch Perception; Preparation; Prevalence; Procedures; Process; Property; Publications; Pulse taking; Rattus; Reporting; Role; Site; Stimulus; Stroke; Study models; Techniques; Testing; Time; Training; auditory discrimination; awake; extracellular; implantation; new technology; relating to nervous system; response; sound; sound frequency; stem

DESCRIPTION (provided by applicant): Deficits in fine-grained auditory pitch perception have been implicated in language learning disorders, certain forms of dyslexia, and more severe neurological conditions. Fine-grained frequency discrimination is believed to be a function of the primary auditory cortex (A1), but the mechanism responsible is still unclear. In the time-course of individual A1 neural responses to iso-frequency tones, relatively non-frequency- selective phasic excitation gives way to more narrowly selective tonic excitation that is sustained throughout the duration of the tone. Tonic responses in A1 may code for fine-grained spectral perception. This study will investigate the role and functionality of tonic responses with respect to pitch perception of pure tones in awake rats using a combination of neural recording, microstimulation, and behavioral techniques. Neural recordings from multichannel electrode arrays will be used to fully characterize tonic neural responses in A1 to iso-frequency tones. A simultaneous neural recording and microstimulation paradigm will be used to examine the contribution of intracortical modulation to processing of iso-frequency stimuli. Finally, microstimulation will be paired with a behavioral paradigm to investigate the perceived pitch of sensation elicited by artificial activation of A1 in a pattern mimicking natural iso-frequency responses. The combination of these techniques will provide a uniquely detailed view of the mechanisms and functionality of tonic responses in A1 with respect to fine-grained pitch perception. This study will help in understanding how the brain breaks down sound information into sound frequency. The knowledge gained from this study could be useful in developing better treatments for childhood language learning disorders or for language disorders stemming from strokes and other brain damage.

描述（由申请人提供）：细粒度听觉感知的缺陷与语言学习障碍、某些形式的阅读障碍和更严重的神经系统疾病有关。细粒度频率辨别被认为是初级听觉皮层 (A1) 的功能，但其机制仍不清楚。在个体 A1 神经对等频率音调的反应的时间过程中，相对非频率选择性的相性兴奋让位于在整个音调持续时间中持续的更窄选择性的强直性兴奋。 A1 中的主音反应可以编码细粒度的光谱感知。本研究将结合神经记录、微刺激和行为技术，研究清醒大鼠纯音音调感知的主调反应的作用和功能。多通道电极阵列的神经记录将用于充分表征 A1 对等频率音调的紧张性神经反应。同时神经记录和微刺激范例将用于检查皮质内调制对等频率刺激处理的贡献。最后，微刺激将与行为范例相结合，以模拟自然等频响应的模式，研究人工激活 A1 所引发的感知音高。这些技术的结合将为 A1 中的主音反应的机制和功能提供关于细粒度音高感知的独特详细视图。这项研究将有助于了解大脑如何将声音信息分解为声音频率。从这项研究中获得的知识可能有助于开发更好的治疗儿童语言学习障碍或中风和其他脑损伤引起的语言障碍的方法。