The Role of Tonic Neural Responses in Auditory Pitch Perception in Awake Rat A1

强直神经反应在清醒大鼠 A1 听觉感知中的作用

• 批准号: 7275562
• 负责人: Andrew Michael Sloan
• 金额: $ 3.3万
• 依托单位: UNIVERSITY OF OKLAHOMA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-22 至 2009-01-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7275562
• 关键词: Acute; Anesthetics; Animals; Auditory; Auditory area; Auditory pitch; Behavior; Behavioral; Behavioral Paradigm; Brain; Brain Injuries; Cereals; Characteristics; Childhood; Classification; Code; Condition; Discrimination; Dyslexia; Electrodes; Esthesia; Fire - disasters; Frequencies; High Prevalence; Human; Implant; Individual; Investigation; Knowledge; Language Development; Language Disorders; Learning Disorders; Masks; Mediation; Neurologic; Neurons; Patients; Pattern; Perception; Performance; Physiologic pulse; Pitch Perception; Preparation; Prevalence; Procedures; Process; Property; Publications; Pulse taking; Rattus; Reporting; Role; Site; Stimulus; Stroke; Study models; Techniques; Testing; Time; Training; auditory discrimination; awake; extracellular; implantation; new technology; relating to nervous system; response; sound; sound frequency; stem

DESCRIPTION (provided by applicant): Deficits in fine-grained auditory pitch perception have been implicated in language learning disorders, certain forms of dyslexia, and more severe neurological conditions. Fine-grained frequency discrimination is believed to be a function of the primary auditory cortex (A1), but the mechanism responsible is still unclear. In the time-course of individual A1 neural responses to iso-frequency tones, relatively non-frequency- selective phasic excitation gives way to more narrowly selective tonic excitation that is sustained throughout the duration of the tone. Tonic responses in A1 may code for fine-grained spectral perception. This study will investigate the role and functionality of tonic responses with respect to pitch perception of pure tones in awake rats using a combination of neural recording, microstimulation, and behavioral techniques. Neural recordings from multichannel electrode arrays will be used to fully characterize tonic neural responses in A1 to iso-frequency tones. A simultaneous neural recording and microstimulation paradigm will be used to examine the contribution of intracortical modulation to processing of iso-frequency stimuli. Finally, microstimulation will be paired with a behavioral paradigm to investigate the perceived pitch of sensation elicited by artificial activation of A1 in a pattern mimicking natural iso-frequency responses. The combination of these techniques will provide a uniquely detailed view of the mechanisms and functionality of tonic responses in A1 with respect to fine-grained pitch perception. This study will help in understanding how the brain breaks down sound information into sound frequency. The knowledge gained from this study could be useful in developing better treatments for childhood language learning disorders or for language disorders stemming from strokes and other brain damage.

描述（由申请人提供）：细粒度听觉音调感知的缺陷与语言学习障碍，某些形式的阅读障碍和更严重的神经系统疾病有关。据信细粒的频率歧视是主要听觉皮层（A1）的函数，但负责的机制仍不清楚。在单个A1神经对ISO频率音调的时间顺序中，相对非频率 - 选择性的阶段激发使位于整个音调的过程中持续的更狭narly的选择性强调。 A1中的补品响应5月代码，以进行细粒光谱感知。这项研究将通过神经记录，微刺激和行为技术的结合来研究补体反应对纯音中纯音调的作用和功能。来自多通道电极阵列的神经记录将用于充分表征A1中的滋补神经反应到ISO频率。同时的神经记录和微刺激范式将用于检查心脏内调节对等频刺激的处理的贡献。最后，微刺激将与行为范式配对，以研究通过模拟自然ISO频率响应的模式中A1的人工激活引起的感知音调。这些技术的组合将提供有关A1在细粒度感知方面的补品反应的机制和功能的独特详细观点。这项研究将有助于了解大脑如何将声音信息分解为声音频率。从这项研究中获得的知识对于开发更好的儿童语言学习障碍或因中风和其他脑部损害而引起的语言障碍可能很有用。