Selenium, Isoflavones, Androgen Metabolism and Prostate Cancer Risk Reduction

硒、异黄酮、雄激素代谢和降低前列腺癌风险

• 批准号: 7253788
• 负责人: MERRILL CHRISTENSEN
• 金额: $ 22.5万
• 依托单位: BRIGHAM YOUNG UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7253788
• 关键词: Adenocarcinoma; Age; Androgen Metabolism; Androgens; Animals; Biochemical; Biological Assay; Blood; Budgets; Chemoprevention; Chemopreventive Agent; Conceptions; Consumption; Critiques; Data; Diet; Dietary Component; Dietary intake; Disease; End Point; Gene Expression; Genes; Grant; Histology; Individual; Intake; Isoflavones; Malignant neoplasm of prostate; Measurement; Metabolism; Molecular; Mus; Numbers; Oxidoreductase; Phytoestrogens; Probability; Prostate; Purpose; Recording of previous events; Reporting; Research; Research Training; Risk; Risk Reduction; Role; Score; Selenium; Standards of Weights and Measures; Students; Time; Tissues; Week; Work; cancer risk; design; feeding; glutathione peroxidase; interest; research study

DESCRIPTION (provided by applicant): The purpose of this study is to elucidate the biochemical and molecular mechanisms by which the interaction of selenium (Se) and phytoestrogens reduces the risk for prostate cancer. The objective is highly significant; if successful, the study could provide useful information on the role of Se and isoflavonoids in prostate cancer. The applicant was very responsive to the previous critiques and has provided with new preliminary data. The hypothesis is significant and the approach is adequate. Additional strength is the applicant's long history of working with students for research training which fulfills the purpose of the R15 grant mechanism. There are some concerns about the overly ambitious study with large number of mice in a short time span and with a limited budget. Nevertheless, the proposed research is seen as potentially important with a high probability for it being successful.

描述（由申请人提供）：本研究的目的是阐明硒 (Se) 和植物雌激素相互作用降低前列腺癌风险的生化和分子机制。目标非常重要；如果成功，该研究可以提供有关硒和异黄酮类化合物在前列腺癌中的作用的有用信息。申请人对之前的批评做出了非常积极的回应，并提供了新的初步数据。假设很重要，方法也很充分。额外的优势是申请人与学生合作进行研究培训的悠久历史，这实现了 R15 资助机制的目的。人们对这项过于雄心勃勃、在短时间内使用大量小鼠、预算有限的研究感到担忧。 尽管如此，拟议的研究被认为具有潜在的重要意义，成功的可能性很高。