In Vivo Optical Detection of Dysplasia in Esophagus

食管发育不良的体内光学检测

• 批准号: 7027674
• 负责人: Lev T Perelman
• 金额: $ 40.78万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-05 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7027674
• 关键词: Barretts esophagus; adenocarcinoma; bioimaging /biomedical imaging; biomarker; biomedical equipment development; clinical research; computer program /software; diagnosis design /evaluation; early diagnosis; endoscopy; gastrointestinal imaging /visualization; histopathology; human subject; light scattering; mathematical model; neoplasm /cancer diagnosis; optics; tissue /cell culture

DESCRIPTION (provided by applicant): The purpose of this program is to provide the gastroenterologist with a diagnostic screening tool which will enable him to rapidly survey the region of Barrett's esophagus (BE) in a patient with this disease, and allow him to determine with high probability and in real-time, regions of dysplasia and carcinoma. It will be able to distinguish between the categories of adenocarcinoma, high-grade dysplasia, low-grade dysplasia, indefinite for dysplasia and non-dysplastic BE. It will be able to perform measurements of the full length of the esophagus in about ten minutes and provide the information in real time. Suspicious areas can then be biopsied and the diagnosis verified. This approach is vastly superior to the present strategies of performing either systematic or random biopsies. Thus it will provide a powerful tool for screening the large population of Barrett's esophagus patients for early precancerous changes. This instrument will be based on the technique of light scattering spectroscopy (LSS), which has been demonstrated in a proof-of-principle study to be able to perform such measurements in the epithelial tissue of five different organs, including BE. The advantages of the proposed technique are that it greatly simplifies the time and labor involved in performing screening and obtaining diagnoses, will cause less patient discomfort, require fewer biopsies, and it can help the pathologist to base his diagnosis on uniform quantitative criteria, making the diagnosis more consistent. Because of these advantages, it should vastly improve the probability of detecting potential malignancies in the early stages, when cures are possible, and it should be highly cost effective. Since tissue is not necessarily removed, it makes possible progression studies. Such studies may determine accurate predicative factors for the outcome of the disease, and thus simplify the decision in the choice of treatment.

描述（由申请人提供）：该程序的目的是为胃肠病学家提供一种诊断筛查工具，使他能够快速调查患有这种疾病的患者的巴雷特食管 (BE) 区域，并允许他确定高概率且实时地发现不典型增生和癌区域。它将能够区分腺癌、高度不典型增生、低度不典型增生、不确定不典型增生和非不典型增生BE的类别。它将能够在大约十分钟内完成食道全长的测量，并实时提供信息。然后可以对可疑区域进行活检并验证诊断。这种方法远远优于目前进行系统或随机活检的策略。因此，它将为筛查大量巴雷特食管患者的早期癌前变化提供强大的工具。 该仪器将基于光散射光谱 (LSS) 技术，该技术已在原理验证研究中证明能够在包括 BE 在内的五个不同器官的上皮组织中进行此类测量。该技术的优点是，它大大简化了进行筛查和获得诊断所涉及的时间和劳动力，会减少患者的不适，需要更少的活检，并且可以帮助病理学家根据统一的定量标准进行诊断，从而使诊断更加准确。诊断更加一致。由于这些优点，它应该大大提高在可以治愈的早期阶段检测出潜在恶性肿瘤的可能性，并且应该具有很高的成本效益。由于不一定要切除组织，因此可以进行进展研究。此类研究可以确定疾病结果的准确预测因素，从而简化治疗选择的决策。