Cognitive Vulnerability to Changes in OC Symptoms

OC 症状变化的认知脆弱性

• 批准号: 7095373
• 负责人: MEREDITH Ellen COLES
• 金额: $ 7.53万
• 依托单位: STATE UNIVERSITY OF NY,BINGHAMTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7095373
• 关键词: Internet; behavioral /social science research tag; belief; clinical research; cognition; computer assisted diagnosis; computer human interaction; data collection methodology /evaluation; depression; developmental psychology; diagnosis design /evaluation; disease /disorder etiology; disease /disorder proneness /risk; early diagnosis; human subject; mental disorder diagnosis; obsessive compulsive disorder; prognosis; psychological stressor; psychological tests; questionnaires; social psychology; university student

DESCRIPTION (provided by applicant): Obsessive-Compulsive Disorder (OCD) is a prevalent problem with important public health implications. OCD affects 2 to 3% of Americans, and is associated with substantial impairment, and direct and indirect economic costs. Nearly 75% of individuals with OCD fail to access treatment and individuals that do access treatment are often left with substantial residual symptoms even after successful treatment. Therefore, empirically-based programs to prevent the development of full-blown OCD would hold great promise in mitigating the negative impact of this disorder. However, a better understanding of the etiology of OCD is needed to inform the development of these prevention programs. SPECIFIC AIMS: Cognitive theories are among the most influential models of OCD. These models propose that negative interpretations of intrusions and stress confer vulnerability to OCD. However, etiological predictions from these models remain untested. The proposed study is innovative in prospectively testing predictors of OC symptom changes hypothesized by cognitive models. DESIGN AND HYPOTHESES: This new investigator initiated R03 will use a sample of 500 young adults during a period of increased stress to test the hypotheses that maladaptive OC-related beliefs, stress (negative life events), and their interaction, will prospectively predict changes in OC symptoms over six months. Further, it is hypothesized that initial OC-related beliefs will significantly more strongly predict changes in OC symptoms than changes in depressive symptoms. A supplementary aim will test the hypothesis that the core study measures will perform similarly when administered via a computer compared to traditional paper and pencil administration, facilitating future longitudinal studies of OCD. SIGNIFICANCE: The proposed study represents an initial step along a line of research clarifying the role of psychosocial factors in the etiology of OCD. If OC-related beliefs and stress prospectively predict increases in OCD symptoms, these variables could be targeted in preventative interventions. Empirically based prevention programs hold great promise for stopping the development of full-blown OCD and eliminating years of needless suffering. Documentation of the feasibility of computer-based administration of study questionnaires would greatly facilitate future longitudinal research on OCD.

描述（由申请人提供）：强迫症 (OCD) 是一个普遍存在的问题，具有重要的公共卫生影响。强迫症影响着 2% 到 3% 的美国人，并会带来严重的损害以及直接和间接的经济损失。近 75% 的强迫症患者未能获得治疗，而接受治疗的人即使在成功治疗后也常常留下严重的残留症状。因此，基于经验的预防强迫症全面发展的计划将有望减轻这种疾病的负面影响。然而，需要更好地了解强迫症的病因学，以便为这些预防计划的制定提供信息。具体目标：认知理论是最有影响力的强迫症模型之一。这些模型提出，对入侵和压力的负面解释会导致强迫症的脆弱性。然而，这些模型的病因学预测仍未经过检验。这项研究在前瞻性测试认知模型假设的 OC 症状变化预测因素方面具有创新性。设计和假设：这位新研究者发起的 R03 将使用 500 名处于压力增加时期的年轻人样本来测试以下假设：适应不良的 OC 相关信念、压力（负面生活事件）及其相互作用将前瞻性地预测生活中的变化。 OC 症状超过六个月。此外，假设最初的 OC 相关信念比抑郁症状的变化更能预测 OC 症状的变化。补充目标将检验这样一个假设：与传统的纸笔管理相比，通过计算机管理时核心研究措施的表现相似，从而促进未来对强迫症的纵向研究。意义：拟议的研究代表了澄清心理社会因素在强迫症病因学中的作用的一系列研究的第一步。如果与强迫症相关的信念和压力前瞻性地预测强迫症症状的增加，那么这些变量就可以成为预防性干预措施的目标。基于经验的预防计划对于阻止强迫症的全面发展和消除多年不必要的痛苦有着巨大的希望。基于计算机的研究问卷管理可行性的记录将极大地促进未来对强迫症的纵向研究。