Age at First Sex, Genes, Religion, and Other Social

第一次性行为的年龄、基因、宗教和其他社会因素

• 批准号: 7130500
• 负责人: Guang Guo
• 金额: $ 7.3万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7130500
• 关键词: adolescence (12-20); age at pregnancy; behavioral /social science research tag; behavioral genetics; biotechnology; child psychology; clinical research; compulsive behavior; developmental psychology; family structure /dynamics; gender difference; gene environment interaction; genetic polymorphism; genetic screening; genotype; high risk behavior /lifestyle; human data; human genetic material tag; human population study; longitudinal human study; religion; sex behavior; sexually transmitted diseases; social psychology; socioeconomics

DESCRIPTION (provided by applicant): Early initiation of sexual intercourse in adolescence has been shown to be a risk factor for teenage pregnancy and sexually transmitted diseases. The goal of this proposed project is to identify the influences of genetic and environmental factors and their interactions on risky sexual behavior in adolescence using a sub-sample of about 2,600 participants of the National Longitudinal Study of Adolescent Health (Add Health). This sub-sample includes measures of adolescent sexual behavior from Waves l-lll (1994-5, 1995-6, and 2002, respectively), DNA data from Wave III, and extensive measures of religious beliefs and practice as well as other social and demographic context. Our Aim 1 will test the main effects of genetic variants and religiosity on age at first sexual intercourse using the candidate gene variants already genotyped in the sibling sub-sample. These analyses will consider polymorphisms in SLC6A3, DRD4, DRD2, SLC6A4, & MAOA as well as measures of religiosity and other social and demographic context including family structure, parental education, occupation, income, and community-level characteristics. Our Aim 2 will test the hypothesis that the effects of genetic variants on age at first sexual intercourse, if they exist, depend on individual's religiosity. We will test the interactive effects between the polymorphisms in SLC6A3, DRD4, DRD2, SLC6A4, & MAOA and religiosity as well as other SES measures. All of these genes have been previously implicated in risky behaviors and have been hypothesized to be associated with the propensities for a variety of compulsive, impulsive, and addictive behaviors including ADHD, substance abuse, alcoholism, smoking, and binge eating. Previous work and our own preliminary work suggest that early initiation of sex is likely to be associated with these genetic variants. Add Health is a pioneer research program that deliberately integrates traditional social sciences with bio- genetic perspectives. Its prospective, longitudinal design, the large range of social, demographic, psychological, & behavioral measures, and the DNA sample will allow for an unprecedented investigation of how environmental factors interact with specific genetic polymorphisms to influence risky sexual behavior among adolescents.

描述（由申请人提供）：青春期过早开始性交已被证明是少女怀孕和性传播疾病的危险因素。该拟议项目的目标是利用国家青少年健康纵向研究（Add Health）约 2,600 名参与者的子样本，确定遗传和环境因素及其相互作用对青少年危险性行为的影响。该子样本包括来自 Waves l-lll（分别为 1994-5、1995-6 和 2002）的青少年性行为测量、来自 Wave III 的 DNA 数据，以及宗教信仰和实践以及其他社会和文化的广泛测量。人口背景。我们的目标 1 将使用已在兄弟姐妹子样本中进行基因分型的候选基因变异来测试遗传变异和宗教信仰对首次性交年龄的主要影响。这些分析将考虑 SLC6A3、DRD4、DRD2、SLC6A4 和 MAOA 的多态性，以及宗教信仰和其他社会和人口背景的测量，包括家庭结构、父母教育、职业、收入和社区层面的特征。我们的目标 2 将检验以下假设：遗传变异对首次性交年龄的影响（如果存在）取决于个人的宗教信仰。我们将测试 SLC6A3、DRD4、DRD2、SLC6A4 和 MAOA 的多态性与宗教信仰以及其他 SES 指标之间的交互作用。所有这些基因以前都与危险行为有关，并被假设与各种强迫、冲动和成瘾行为的倾向有关，包括多动症、药物滥用、酗酒、吸烟和暴饮暴食。之前的工作和我们自己的初步工作表明，过早开始性行为可能与这些遗传变异有关。 Add Health 是一项先锋研究计划，有意将传统社会科学与生物遗传学观点相结合。其前瞻性、纵向设计、大范围的社会、人口、心理和行为测量以及 DNA 样本将允许对环境因素如何与特定基因多态性相互作用以影响青少年的危险性行为进行前所未有的调查。