PRIDE: Program to Reduce Incontinence by Diet & Exercise

PRIDE：通过饮食减少失禁的计划

• 批准号: 7489220
• 负责人: Deborah G Grady
• 金额: $ 22.46万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7489220
• 关键词: Behavioral; Body Weight decreased; Caring; Clinical; Clinical Trials; Data; Frequencies; Health; Incontinence; Institution; Intervention; Maintenance; Methods; Motivation; Obesity; Outcome; Overweight; Quality of life; Randomized; Research Design; Research Personnel; Risk; Standards of Weights and Measures; Upper arm; Urinary Incontinence; Weight maintenance regimen; Woman; Women' s Health; base; behavior change; daily functioning; diet and exercise; experience; innovation; novel; novel strategies; obesity treatment; programs; skills; theories; weight maintenance

Urinary incontinence Is a commonproblem among women that causesdistress, diminished quality of life and dramatic limitations in daily functioning. Overweight womenare at significantly increased risk of urinary incontinence and over 65% of womenwith incontinence are overweight. Data from short-term, preliminary studies suggestthat weight reduction may significantly reduce incontinence episodes. Thus, weightless may present a promising new approach to urinary incontinence treatment,one likely to produce a cascadeof broader health improvements in addition to reductions in frequencyof urinary incontinence. Therefore, we propose to randomize 330 overweight and obese womenwith urinary incontinence (165 at each of two clinical centers) to a 6-month intensive behavioral weight control programor to usual care to determine the short-term effect of weight loss on frequency of incontinence and quality of life, to identify women most likely to benefit from weight loss and to beginto explore the urodynamicmechanisms underlying incontinence improvement following weight loss. To maximize enduring effects of weight loss on urinary incontinence, it will be necessary to produce sustained weight loss. However, weight maintenance remainsa challenge in the obesity field. Therefore, we propose to evaluate an innovative, theory-guided weight maintenance program that will focus on increasing motivation and commitment to behavior change efforts and comparethis with a more standard, skills-focused weight maintenance program.After completing the 6-month weight loss program,women in the weight loss arm will be randomizedto either a 12-month standard, skill-based maintenance programor to a motivationally-focused maintenance intervention. Outcomes will include weight loss, incontinence frequency and quality of life at 18 months. If effective in women with incontinence, the methods and strategies of this innovative motivationally-focused maintenance intervention can be examined in other obesepopulations. WIN- Weight Reduction for Incontinence Network- brings together a unique group of outstanding and experienced investigators with expertise in urinary incontinence, obesity treatment and multicenter collabora- tive clinical trials at three Institutions, The proposed study design will allow us to efficiently evaluate both a novel treatment for urinary incontinence and a promising approach to enhancement of weight maintenance, and therefore to make substantive contributions to severalclinical arenas critical to women's health.

尿失禁是导致女性的女性中常见问题，生活质量降低 以及日常功能的巨大限制。超重妇女的尿风险显着增加 尿失禁和超过65％的女性失禁超重。来自短期，初步的数据 研究表明，减轻体重可能会大大减少尿失禁发作。因此，失重可能 提出了一种有希望的新方法进行尿失禁治疗，一种可能会产生级联 除了减少尿失禁频率外，更广泛的健康改善。因此，我们 建议随机尿失禁330超重和肥胖女性（两个 临床中心）到一个为期6个月的强化行为重量控制程序员，以确定 体重减轻对尿失禁和生活质量频率的短期影响，以确定最有可能的女性 从体重减轻中受益并探索尿失禁的尿动力学 体重减轻后的改善。 为了最大程度地减轻体重减轻对尿失禁的影响，有必要产生 持续体重减轻。但是，肥胖领域的体重维持仍然是挑战。所以， 我们建议评估一种创新的，理论指导的体重维护计划，该计划将重点放在 增加动力和对行为改变努力的承诺，并与更标准的相比 以技能为中心的体重维持计划。完成为期6个月的减肥计划后 减肥臂将被随机分为12个月标准，基于技能的维护程序员 以动力为中心的维护干预。结果将包括减肥，尿失禁频率 和18个月的生活质量。如果对有尿失禁的女性有效，那么这种方法和策略 可以在其他肥胖症中检查以创新的动力维护干预措施。 失禁网络的胜利降低 - 汇集了一群独特的杰出和 经验丰富的研究人员具有尿失禁，肥胖治疗和多中心合作方面的专业知识 在三个机构的临床试验中，拟议的研究设计将使我们能够有效地评估这两个 新的尿失禁治疗和一种有希望的增强体重维持的方法， 因此，为对妇女健康至关重要的几个临床领域做出实质性贡献。

项目成果

Sexual function among overweight and obese women with urinary incontinence in a randomized controlled trial of an intensive behavioral weight loss intervention.

在一项强化行为减肥干预的随机对照试验中，患有尿失禁的超重和肥胖女性的性功能。

• DOI: 10.1016/j.juro.2009.01.046
• 发表时间: 2009
• 期刊: The Journal of urology
• 作者: Huang,AlisonJ;Stewart,AnitaL;Hernandez,AlexandraL;Shen,Hui;Subak,LesleeL;ProgramtoReduceIncontinencebyDietandExercise
• 通讯作者: ProgramtoReduceIncontinencebyDietandExercise

Urodynamic characterization of obese women with urinary incontinence undergoing a weight loss program: the Program to Reduce Incontinence by Diet and Exercise (PRIDE) trial.

• DOI: 10.1007/s00192-008-0694-8
• 发表时间: 2008-12
• 期刊: INTERNATIONAL UROGYNECOLOGY JOURNAL
• 影响因子: 1.8
• 作者: Richter, Holly E.;Creasman, Jennifer M.;Myers, Deborah L.;Wheeler, Thomas L.;Burgio, Kathryn L.;Subak, Leslee L.
• 通讯作者: Subak, Leslee L.

A motivation-focused weight loss maintenance program is an effective alternative to a skill-based approach.

• DOI: 10.1038/ijo.2010.138
• 发表时间: 2011-02
• 期刊: INTERNATIONAL JOURNAL OF OBESITY
• 影响因子: 4.9
• 作者: West, D. S.;Gorin, A. A.;Subak, L. L.;Foster, G.;Bragg, C.;Hecht, J.;Schembri, M.;Wing, R. R.
• 通讯作者: Wing, R. R.

Time in Bed is Associated with Decreased Physical Activity and Higher BMI in Women Seeking Weight Loss Treatment.

对于寻求减肥治疗的女性来说，卧床时间与体力活动减少和体重指数较高有关。

• DOI: 10.5402/2012/320157
• 发表时间: 2012
• 期刊: ISRN obesity
• 作者: Hart,ChantelleN;Fava,JosephL;Subak,LesleeL;Stone,Katie;Vittinghoff,Eric;Demos,Kathryn;O'Brien,Erin;Cairns,Alyssa;Wing,Rena
• 通讯作者: Wing,Rena

Comparison and correlates of three preference-based health-related quality-of-life measures among overweight and obese women with urinary incontinence.

• DOI: 10.1007/s11136-011-9896-5
• 发表时间: 2011-12
• 期刊: QUALITY OF LIFE RESEARCH
• 影响因子: 3.5
• 作者: Pinto, Angela Marinilli;Kuppermann, Miriam;Nakagawa, Sanae;Vittinghoff, Eric;Wing, Rena R.;Kusek, John W.;Herman, William H.;Subak, Leslee L.
• 通讯作者: Subak, Leslee L.