Responses to Energy & Mock Healing in Fatigued Survivors

对能源的反应

• 批准号: 7274432
• 负责人: SHAMINI JAIN
• 金额: $ 3.64万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7274432
• 关键词: Adjuvant; Adverse effects; Biological Assay; Cancer Patient; Cancer Survivor; Cell Adhesion Molecules; Clinical Research; Clinical Trials; Dimensions; Disease; End Point; Enzymes; Fatigue; Funding; Hand; Healed; Hormonal; Hormones; Hospitals; Hydrocortisone; Immune; Inflammatory; Intercellular adhesion molecule 1; Interleukin-1; Intervention; Laboratories; Link; Measures; Mental Depression; Modality; Neoadjuvant Therapy; Nursing Staff; Outcome Measure; Participant; Patient Self-Report; Plasma; Protocols documentation; Psychological Factors; Quality of life; Radioimmunoassay; Randomized; Recurrence; Relative (related person); Religion and Spirituality; Reporting; Salivary; Self Care; Survivors; Techniques; Touch sensation; Ursidae Family; Week; Woman; absorption; cancer therapy; clinically relevant; clinically significant; design; experience; healing; human TNFRSF1A protein; improved; malignant breast neoplasm; psychologic; receptor; response; treatment effect; tumor necrosis factor alpha receptor

DESCRIPTION (provided by applicant): Breast cancer survivors are high users of CAM modalities including hands-on healing techniques. This competing continuation proposal examines the short-term impact of energy healing vs. mock healing for fatigued breast cancer survivors, and explores whether certain factors (i.e., worldview, absorption, and religious and/or spiritual variables) are associated with positive responses to treatment. Outcome measures include self-reports of fatigue, depression and quality of life as well as inflammatory immune (soluble intracellular adhesion molecule and tumor necrosis factor alpha receptor II) and hormonal (cortisol) markers that are associated with these psychological factors and bear clinical relevance for breast cancer. This is a two-group design in which 50 participants are randomized to five sessions of either energy healing or mock energy healing over a one-month period. It is hypothesized that treatment with energy healing will be associated with lower fatigue and improved psychological functioning, as well as decreases in inflammatory j markers and cortisol levels. A secondary hypothesis is that participants whose worldviews match the j holistic principles of energy healing will report greater benefits from treatment than those with non-matching worldviews, and that this benefit will be specific to energy healing vs. mock healing. The protocol takes place at the UCSD General Clinical Research Center (GCRC), where full nursing staff and laboratory support is provided, as well as hospital rooms for healing and mock healing treatments. Hormonal and inflammatory immune measures will be measured by radioimmunoassay and enzyme-linked immunosorbant assays (ELISAs). Results from this study will provide breast cancer survivors with important information about the relative efficacy of hands-on healing techniques vs. simple touch for alleviating fatigue after cancer treatment, to aid in choosing modalities for their self-care. For the reasons fully explained in detail in section #27, the PI is requesting an additional year of funding for this 2 year F31 in order to complete this clinical trial, which is her dissertation project.

描述（由申请人提供）：乳腺癌幸存者是CAM模式的高度使用者，包括动手康复技术。这项竞争性延续建议研究了能量康复与模拟愈合对疲劳乳腺癌幸存者的短期影响，并探讨某些因素（即世界观，吸收，宗教和/或精神变量）是否与对治疗的积极反应有关。结果措施包括疲劳，抑郁和生活质量以及炎症免疫（可溶性细胞内粘附分子和肿瘤坏死因子α受体II）和激素（皮质溶酶体）（皮质醇）标记（与这些心理因子和乳腺癌临床相关性相关的荷尔蒙（皮质溶酶））。这是一个两组设计，其中有50名参与者在一个月的时间内随机分配了五个能量愈合或模拟能量愈合的会议。假设能量愈合的治疗将与较低的疲劳和改善的心理功能以及炎症J标记和皮质醇水平降低有关。一个次要假设是，与无匹配的世界观的参与者相匹配的世界观与能量康复的整体原理相匹配将报告的好处更大，并且这种好处将针对能量康复与模拟康复。该协议在UCSD一般临床研究中心（GCRC）举行，提供了全面的护理人员和实验室支持，以及用于康复和模拟治疗治疗的医院。荷尔蒙和炎症免疫测量将通过放射免疫测定法和酶联免疫吸附测定法（ELISA）来测量。这项研究的结果将为乳腺癌幸存者提供有关动手康复技术相对疗效与简单触摸的相对功效的重要信息，以减轻癌症治疗后的疲劳，以帮助选择其自我保健方式。由于第27节中详细解释的原因，PI要求为这项2年F31提供额外的资金，以完成该临床试验，这是她的论文项目。