DESIGN, RANDOMIZATION AND ANALYSIS CORE

设计、随机化和分析核心

• 批准号: 7114740
• 负责人: CONSTANTINE E FRANGAKIS
• 金额: $ 6.43万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7114740
• 关键词: academic achievement; aging; behavioral /social science research tag; biomedical facility; data quality /integrity; elementary school; experimental designs; functional ability; health science research analysis /evaluation; human data; human old age (65+); interdisciplinary collaboration; middle childhood (6-11); quality of life; social model; statistical service /center; statistics /biometry; volunteer

The Randomization and Analysis Core (Core D) is focused on empowering our scientific investigators with first-rate statistical reasoning and analytic support that are needed to ensure the successful implementation and analysis of the proposed Experience Corps (EC) Trials. It specifically aims to perform four key functions. First, the Core will support for the design and Implementation of randomization of EC schools and older adult volunteers. Second it will provide coordinated statistical support for validly addressing the aims of this Program Project by collaborating with investigators in all projects in the design of statistical analyses and standardizing the application of high-level analyses shared by multiple projects. Third, it will serve as an intellectual partnership and quantitative resource for other EC cores by assisting the Recruitment and Retention Core (Core B)'s evaluation of the effectiveness of recruitment, retention, and recruitment messages and strategies targeting different subgroups; assisting with the Data Collection and management Core (Core C)'s quality control analyses and development of analytic datasets; and contributing to the collective understanding by the Administrative Core (Core A) and project investigators of the results from specific studies. Finally, in collaboration with Core, C, Core D will support the needs of the Data safety and Monitoring Board by analysis of adverse events and provision of appropriate data in a timely manner. By bringing in a critical mass of dedicated statistical expertise, infrastructure, and staffing to this project, we will be able to overcome the serious challenges that community trials poses for statistical analysis and hence improve our ability to derive critical evidence that is needed locally and nationally to take a high quality program to scale to improve the health of our senior citizens and support the success of our children.

随机分析和分析核心（核心D）的重点是使我们的科学研究人员用 一流的统计推理和分析支持，以确保成功实施 以及对拟议体验兵队（EC）试验的分析。它特别旨在执行四个关键功能。 首先，核心将支持EC学校和老年人随机化的设计和实施 志愿者。第二，它将为有效解决此目的提供协调的统计支持 通过与研究人员合作在统计分析设计中与研究人员合作的计划项目 标准化多个项目共享的高级分析的应用。第三，它将用作 通过协助招聘和 保留核心（Core B）对招聘，保留和招聘有效性的评估 针对不同子组的消息和策略；协助数据收集和管理 Core（Core C）的质量控制分析和分析数据集的开发；并为 行政核心（核心A）的集体理解和项目调查人员从 具体研究。最后，与Core，C，CoreD合作，CoreD将支持数据安全的需求 通过分析不良事件并及时提供适当的数据来监视委员会。经过 为该项目带来大量专门的统计专业知识，基础架构和人员配备，我们将 能够克服社区试验对统计分析提出的严重挑战 提高我们获得在当地和全国需要获得高质量的关键证据的能力 规模扩大的计划，以改善我们的老年人的健康并支持我们孩子的成功。