DNA Replication and Genome Integrity

DNA 复制和基因组完整性

• 批准号: 7162244
• 负责人: Matthew D. Weitzman
• 金额: $ 0.5万
• 依托单位: SALK INSTITUTE FOR BIOLOGICAL STUDIES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7162244
• 关键词: DNA replication; genome; meeting /conference /symposium; travel

DESCRIPTION (provided by applicant): This proposal requests funds to sustain a biennial meeting entitled "DNA Replication and Genome Integrity" that will be held August 9-13, 2006, at the Salk Institute in La Jolla, California. This meeting is designed to emphasize the intersection of DNA replication with DNA repair and genome stability. These areas are relevant to human health, including the etiology, diagnosis and treatment of cancer, aging, and developmental diseases. The meeting will encourage a deeper understanding of links between cellular replication and repair systems. Outstanding researchers have been invited to serve as chairs and speakers in sessions that will cover topics that include replication origins, initiation of DNA replication, replication fork progression, chromatin, checkpoints, chromosome dynamics, DNA repair, recombination, and cancer therapeutics. These chairs will provide in-depth introductions to the most important concepts and unresolved problems in each field. All other presentations will be chosen from submitted abstracts for either oral talks or posters. In this way we will ensure that the forefront of research is presented and will encourage active participation of younger researchers. The Organizing Committee consists of four investigators from two institutions: Judith Campbell (CalTech), Vicki Lundblad (Salk), Geoff Wahl (Salk), and Matthew Weitzman (Salk). The Organizing Committee will be responsible for inviting the session chairs, for selection of the other speakers and participants from submitted abstracts and for choosing recipients for travel awards. The meeting will be held in the Salk Conference Center, a well-organized facility with much experience in conducting international meetings. A concerted effort will be made at every stage of the planning and organization of the meeting to ensure inclusion of women and minorities. We request funds to cover the travel costs and accommodation for a Keynote speaker, invited speakers, and travel scholarships (some of which will be allocated specifically for minorities). This conference complements both temporally and geographically the current biennial DNA replication meeting held at Cold Spring Harbor in odd-numbered years. This will be the fourth time that we have organized this meeting and its past success has shown that it fills a thematic, geographical and timely niche. The meeting has provided a forum for discussion of the most topical issues confronting eukaryotic DNA replication and has fostered interactions between junior and senior investigators. Due to its West Coast location, increased participation from West Coast and Pacific labs is expected. We anticipate that the topics presented and the comfortable venue will encourage new researchers to enter this important field, as well as provide experienced researchers with the new approaches needed to make significant future advances.

描述（由申请人提供）：该提案请求资金来维持题为“DNA 复制和基因组完整性”的两年一次的会议，该会议将于 2006 年 8 月 9 日至 13 日在加利福尼亚州拉霍亚的索尔克研究所举行。 这次会议旨在强调 DNA 复制与 DNA 修复和基因组稳定性的交叉。 这些领域与人类健康相关，包括癌症、衰老和发育疾病的病因、诊断和治疗。 这次会议将鼓励人们更深入地了解细胞复制和修复系统之间的联系。杰出的研究人员被邀请担任会议的主席和发言人，会议主题包括复制起源、DNA 复制起始、复制叉进展、染色质、检查点、染色体动力学、DNA 修复、重组和癌症治疗。这些主席将深入介绍每个领域最重要的概念和未解决的问题。 所有其他演示文稿将从提交的口头报告或海报摘要中选出。 通过这种方式，我们将确保呈现最前沿的研究成果，并鼓励年轻研究人员的积极参与。 组委会由来自两个机构的四名调查员组成：Judith Campbell（加州理工学院）、Vicki Lundblad（索尔克）、Geoff Wahl（索尔克）和 Matthew Weitzman（索尔克）。 组委会将负责邀请会议主席、从提交的摘要中选择其他发言者和参与者以及选择旅行奖获得者。 会议将在索尔克会议中心举行，该中心组织良好，在举办国际会议方面拥有丰富的经验。 将在会议规划和组织的每个阶段共同努力，确保妇女和少数群体的参与。 我们请求资金来支付主旨演讲者、受邀演讲者的旅行费用和住宿以及旅行奖学金（其中一些将专门分配给少数族裔）。此次会议在时间和地理上对目前每两年在冷泉港举行的奇数年 DNA 复制会议进行了补充。 这将是我们第四次组织这次会议，其过去的成功表明，它填补了主题、地域和及时性的空缺。 这次会议为讨论真核 DNA 复制面临的最热门问题提供了一个论坛，并促进了初级和高级研究人员之间的互动。 由于其位于西海岸，预计西海岸和太平洋实验室的参与将会增加。 我们预计所提出的主题和舒适的场地将鼓励新的研究人员进入这一重要领域，并为经验丰富的研究人员提供未来取得重大进展所需的新方法。