Understanding the Impact of Multiple Symptoms: A Symptom Burden Consortium

了解多种症状的影响：症状负担联盟

• 批准号: 7169340
• 负责人: CHARLES S CLEELAND
• 金额: $ 0.3万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7169340
• 关键词: measurement; neoplasm /cancer

DESCRIPTION (provided by applicant): The assessment of certain symptoms in cancer patients such as pain and depression is relatively mature within the cancer population; however, cancer patients and cancer survivors often have other distressing symptoms, such as cachexia, sleep disturbance, fatigue, and cognitive impairment. Measurement of these symptoms is evolving but is often less clearly delineated. Measuring any one of those symptoms may fall short of capturing the burden of distress that the patient is experiencing. Thus, measuring multiple symptoms simultaneously, both in practice and in research, is an area in need of further investigation. This consortium, organized by the Department of Symptom Research, at The University of Texas M. D. Anderson Cancer Center, provides a venue for scientific presentations and collaborative discussions on the development of coherent measurement methods that will allow comparison of symptom burden across clinical trials, epidemiologic studies, and clinical practice. The specific aims of this conference are: To specifically delineate the concept of symptom burden; To provide a collaborative discussion among pharmaceutical industry scientists, federal policy makers, and academic research investigators about improving the scientific infrastructure to manage the complex problems caused by multiple symptoms.; To stimulate collaborative and interdisciplinary research to better understand the etiologic mechanism of multiple symptoms.; To examine and standardize the measurement methods for specific symptoms within the context of a high burden of illness.; To compose a state of the science document, summarizing the recommendations for standardizing measurement methods of specific symptoms within the context of a high burden of illness. The document will be a collaborative effort among consortium participants, and will be submitted to a leading scientific peer-reviewed journal.

描述（由申请人提供）：对癌症患者某些症状（例如疼痛和抑郁）的评估在癌症人群中相对成熟；然而，癌症患者和癌症幸存者经常出现其他令人痛苦的症状，例如恶病质、睡眠障碍、疲劳和认知障碍。 对这些症状的测量正在不断发展，但通常不太明确。 测量这些症状中的任何一种都可能无法捕捉到患者正在经历的痛苦负担。 因此，在实践和研究中同时测量多种症状是一个需要进一步研究的领域。该联盟由德克萨斯大学 M. D. 安德森癌症中心症状研究系组织，为科学演示和协作讨论提供了一个场所，以开发连贯的测量方法，从而可以比较临床试验、流行病学研究中的症状负担和临床实践。 本次会议的具体目标是： 具体界定症状负担的概念；为制药行业科学家、联邦政策制定者和学术研究人员提供协作讨论，以改善科学基础设施以管理由多种症状引起的复杂问题。促进协作和跨学科研究，以更好地了解多种症状的病因机制。在高疾病负担的背景下检查和标准化特定症状的测量方法。 撰写科学文件现状，总结在高疾病负担背景下标准化特定症状测量方法的建议。该文件将是联盟参与者之间的合作成果，并将提交给领先的科学同行评审期刊。