Tissue Engineering Evaluation Criteria for Musculoskeletal Tissue Repair

肌肉骨骼组织修复的组织工程评价标准

• 批准号: 7225830
• 负责人: DAVID L BUTLER
• 金额: $ 1.8万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7225830
• 关键词: meeting /conference /symposium; musculoskeletal system; regeneration; tissue engineering; travel

DESCRIPTION (provided by applicant): In the last two decades, tissue engineering in academia and industry has become an exciting, multidisciplinary field offering the potential to repair or regenerate injured and diseased musculoskeletal and craniofacial tissues with living tissues. With this activity has come the need to allocate resources and choose among competing approaches. This challenge raises questions about criteria used to assess differing approaches. Which approaches are worth funding and what criteria should be used to monitor their success? Which parameters should be measured and what values should these parameters have? We propose to conduct a 2 1/2 day conference that will bring together bioengineers, surgeons, biologists, material scientists, and experts in commercial development to: 1) carefully reexamine general and tissue-specific goals for tissue engineering; 2) identify and prioritize criteria and threshold values for the design and evaluation of these tissue engineered repairs; and 3) identify needs in pre-clinical research to more rapidly achieve our goals. The entire group will meet at the beginning of each day to agree on the process for setting goals, criteria, and threshold values, and then at the end of the day to share results so as to identify common features of these parameters across tissue types. Participants will also be assigned to one of six tissue-specific teams (ligament, tendon, bone, articular cartilage, meniscus/TMJ and intervertebral disc) to include at least one bioengineer, surgeon, biologist, and material scientist. Each team will discuss overall goals and clinical needs, evaluative parameters and criteria for evaluating a specific tissue repair, establish where we are relative to these goals and possible threshold values of acceptability, and examine issues of efficacy, surgical handling and attachment, cost to manufacture, and projected times to preclinical and clinical trials. By continually questioning our progress along the way, we should be able to better assess promising tissue engineering approaches, assist funding agencies to most effectively spend their available research dollars in tissue engineering, and speed the development of useful products to clinical use.

描述（由申请人提供）：在过去的二十年中，学术界和工业界的组织工程已成为一个令人兴奋的多学科领域，提供了用活组织修复或再生受伤和患病的肌肉骨骼和颅面组织的潜力。随着这项活动的开展，需要分配资源并在竞争方法中进行选择。这一挑战引发了有关评估不同方法的标准的问题。哪些方法值得资助以及应该使用什么标准来监控其成功？应该测量哪些参数以及这些参数应该具有什么值？我们建议举办一次为期 2 1/2 天的会议，将生物工程师、外科医生、生物学家、材料科学家和商业开发专家聚集在一起，以：1）仔细重新审查组织工程的一般目标和组织特异性目标； 2) 确定并优先考虑用于设计和评估这些组织工程修复的标准和阈值； 3) 确定临床前研究的需求，以更快地实现我们的目标。整个小组将在每天开始时开会，就设定目标、标准和阈值的过程达成一致，然后在一天结束时分享结果，以确定跨组织类型的这些参数的共同特征。参与者还将被分配到六个特定组织团队（韧带、肌腱、骨骼、关节软骨、半月板/颞下颌关节和椎间盘）之一，其中至少包括一名生物工程师、外科医生、生物学家和材料科学家。每个团队将讨论总体目标和临床需求、评估特定组织修复的评估参数和标准，确定我们与这些目标的相对位置和可接受的可能阈值，并检查功效、手术处理和附着、制造成本等问题，以及临床前和临床试验的预计时间。通过不断质疑我们一路走来的进展，我们应该能够更好地评估有前景的组织工程方法，协助资助机构最有效地将其可用的研究资金用于组织工程，并加快将有用产品开发到临床使用。