Biological Age and Capacity for Self-Management: Implications for Nursing

生物年龄和自我管理能力：对护理的影响

基本信息

批准号：
7256356
负责人：
KATHLEEN C INSEL
金额：
$ 7.25万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-07-07 至 2008-12-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7256356
关键词：
Accounting Acute Address Adherence Age Age-Years Biological Aging Biological Markers Cells Chronic Clinical Cognitive Cognitive aging Condition Discipline of Nursing Elderly Failure Hypertension Impaired health Individual Investigation Length Literature Longevity Measures Methods Monitor Oxidative Stress Performance Persons Pharmaceutical Preparations Population Process Purpose Rate Risk Factors Self Care Self Management Severities Severity of illness Short-Term Memory Source Telomere Shortening Thinking Vascular System Vascular remodeling Work age related base cognitive function distraction executive function medication compliance middle age telomere young adult

Accounting Acute Address Adherence Age Age-Years Biological Aging Biological Markers Cells Chronic Clinical Cognitive Cognitive aging Condition Discipline of Nursing Elderly Failure Hypertension Impaired health Individual Investigation Length Literature Longevity Measures Methods Monitor Oxidative Stress Performance Persons Pharmaceutical Preparations Population Process Purpose Rate Risk Factors Self Care Self Management Severities Severity of illness Short-Term Memory Source Telomere Shortening Thinking Vascular System Vascular remodeling Work age related base cognitive function distraction executive function medication compliance middle age telomere young adult

展开

项目摘要

DESCRIPTION (provided by applicant): The purpose of this investigation is to examine the association between biological age and executive function/working memory among individuals with hypertension. Prior investigations suggest executive function and working memory capacity are important cognitive processes essential for self-management. In addition to the importance of these processes to understanding self-management, it has been shown that executive function and working memory decline with age. This would seem to implicate age as a risk factor for failure to self-manage, for example, medications. This, however, has not been demonstrated. Several investigations suggest that chronological age is a poor predictor of self-management capacity and indeed that older adults may be better on some everyday tasks than young counterparts. While chronological age is not implicated in self-management, it is possible that biological age is a predictor of executive function/ working memory capacity in clinical populations accounting for differences in self-management. This descriptive correlational study uses telomere length as a marker for biological age and examines the association of telomere length to executive function/working memory capacity among individuals > 50 years of age self-managing one prescribed medication for hypertension. The study also identifies oxidative stress as a likely mechanism for accelerated biological aging in persons with hypertension. Oxidative stress will be quantified and associated with disease severity, biological age and executive function/working memory capacity. The study also seeks to provide converging evidence for the association between executive function/working memory capacity and medication adherence, an established self-management activity.

描述（由申请人提供）：这项调查的目的是检查高血压患者之间生物年龄与执行功能/工作记忆之间的关联。先前的调查表明，执行功能和工作记忆能力是自我管理必不可少的重要认知过程。除了这些过程对理解自我管理的重要性外，还表明执行功能和工作记忆随着年龄的增长而下降。这似乎将年龄视为无法自我管理的危险因素，例如药物。但是，这尚未得到证明。几项调查表明，按时间顺序的年龄是自我管理能力的差预测指标，实际上，老年人在某些日常任务上可能比年轻的年轻人更好。尽管按年代年龄与自我管理无关，但生物年龄可能是临床人群中执行功能/工作记忆能力的预测指标，从而考虑了自我管理的差异。这项描述性相关研究使用端粒长度作为生物年龄的标记，并研究了端粒长度与执行功能/工作记忆能力的关联> 50岁以上的人自我管理一种用于高血压的处方药。该研究还确定了氧化应激是高血压患者加速生物衰老的可能机制。氧化应激将被量化并与疾病的严重程度，生物年龄和执行功能/工作记忆能力有关。该研究还旨在为执行功能/工作记忆能力和药物依从性（已建立的自我管理活动）之间的关联提供融合的证据。