Adipogenesis, Obesity and Inflammation

脂肪生成、肥胖和炎症

• 批准号: 7002097
• 负责人: PHILIPP E SCHERER
• 金额: $ 2万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-15 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7002097
• 关键词: adipocytes; atherosclerosis; cell differentiation; inflammation; insulin sensitivity /resistance; meeting /conference /symposium; metabolic syndrome; noninsulin dependent diabetes mellitus; obesity; travel

DESCRIPTION (provided by applicant): The worldwide epidemic in obesity has brought with it dramatic increases in the prevalence of associated diseases, including insulin resistance, type 2 diabetes, the metabolic syndrome, and atherosclerosis, the rapid rise in these major public health problems underscores a growing need to understand the physiological and pathological bases of feeding and obesity, and the links between obesity and these associated morbidities. This meeting will focus on the biology of the cell type at the center of all of these diseases, the adipocyte as well as on recent advances being made in our understanding of the molecular basis of feeding and nutrient storage and on the molecular consequences of obesity in terms promoting risk of developing diabetes and cardiovascular disease. Specific topics related to potential causes of obesity include: I) Central regulation of feeding and adiposity, II) Genetic defects leading to obesity, and III) Adipogenesis and adipocyte differentiation. Topics related to the consequences of obesity include: I) Adipokines and other products of adipocytes, II) Inflammation in fat and other organs and the recruitment and involvement of macrophages, III) Accumulation of lipids and adipocytes in other organs, IV) Etiology of the metabolic syndrome and association with atherosclerosis. Special attention will be given to translational insights that highlight some of the clinical implications of excess storage of adipose tissue. Some sessions will be held jointly with the "Diabetes Mellitus and the control of Cellular Energy Metabolism" meeting that will effectively complement the obesity meeting.

描述（由申请人提供）： 肥胖症在全球范围内的流行带来了相关疾病患病率的急剧增加，包括胰岛素抵抗、2型糖尿病、代谢综合征和动脉粥样硬化，这些主要公共卫生问题的迅速增加凸显了人们越来越需要了解肥胖的生理机制。喂养和肥胖的病理基础，以及肥胖与这些相关疾病之间的联系。本次会议将重点讨论所有这些疾病的核心细胞类型——脂肪细胞的生物学，以及我们在理解喂养和营养储存的分子基础以及肥胖对肥胖的分子后果的理解方面所取得的最新进展。增加患糖尿病和心血管疾病风险的术语。与肥胖潜在原因相关的具体主题包括：I) 喂养和肥胖的中枢调节，II) 导致肥胖的遗传缺陷，以及 III) 脂肪生成和脂肪细胞分化。与肥胖后果相关的主题包括：I) 脂肪因子和脂肪细胞的其他产物，II) 脂肪和其他器官的炎症以及巨噬细胞的募集和参与，III) 其他器官中脂质和脂肪细胞的积累，IV) 肥胖的病因学代谢综合征及其与动脉粥样硬化的关联。将特别关注强调脂肪组织过度储存的一些临床影响的转化见解。部分分会场将与“糖尿病与细胞能量代谢的控制”会议联合举办，有效补充肥胖会议。

项目成果

Keystone meeting summary: 'Adipogenesis, obesity, and inflammation' and 'Diabetes mellitus and the control of cellular energy metabolism, ' January 21-26, 2006, Vancouver, Canada.

重点会议摘要：“脂肪形成、肥胖和炎症”和“糖尿病和细胞能量代谢的控制”，2006 年 1 月 21-26 日，加拿大温哥华。

• 发表时间: 2006-08-15
• 作者: Corvera, Silvia;Burkart, Alison;Kim, Ja;Christianson, Jennifer;Wang, Zhao;Scherer, Philipp E
• 通讯作者: Scherer, Philipp E