Prenatal Nutrition and Adverse Birth Outcomes in HIV-Infected Women in Malawi

马拉维艾滋病毒感染妇女的产前营养和不良分娩结果

• 批准号: 7391873
• 负责人: Linda S Adair
• 金额: $ 7.06万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2010-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7391873
• 关键词: AIDS/HIV problem; Affect; Africa South of the Sahara; Anti-Retroviral Agents; Area; Attention; Birth; Birth length; Breast Feeding; Caring; Centers for Disease Control and Prevention (U.S.); Clinic; Clinical Trials; Clinical Trials Design; Communities; Counseling; Data; Databases; Diet; Dietary Intervention; Dietary intake; Disease Progression; Economics; Energy Intake; Enrollment; Equilibrium; Face; Family; Fatty acid glycerol esters; Female of child bearing age; Food; Food Packaging; Food Supplements; Funding; Gestational Age; HIV; HIV Seropositivity; Head circumference; Health; Health Status; Hospital Records; Hour; Individual; Infant; Infection; Intake; Knowledge; Left; Life; Low Birth Weight Infant; Maize; Malawi; Malnutrition; Maternal Health; Muscle; Newborn Infant; Nutritional; Nutritional status; Outcome; Participant; Patient currently pregnant; Pattern; Personal Satisfaction; Physiological; Play; Poverty; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Prenatal Nutrition; Proteins; Records; Research; Resources; Risk; Role; Skinfold Thickness; Surveys; Triceps Brachii Muscle; Upper arm; Vegetable Oils; Vertical Disease Transmission; Vitamin A; Weight; Woman; Work; Workload; Zea mays; coping; food quality; improved; mother nutrition; nutrition; programs; size; soy; therapy design; toe corn

DESCRIPTION (provided by applicant): In sub-Saharan Africa, an estimated 13.5 million women of childbearing age are infected with HIV. When they become pregnant, HIV-infected woman face not only the usual physiological and nutritional demands of pregnancy, but also the extra demands imposed by infection. In settings with a high level of food insecurity and high maternal work loads, women may be unable to consume sufficient high quality food to meet these heightened nutritional needs, leaving them at much greater risk of poor health, faster disease progression and increased risk of poor birth outcomes. Most research related to HIV in pregnancy has focused on antiretroviral strategies to reduce mother to child transmission (MTCT) of HIV. Little attention has been paid to maternal health and nutrition status. The proposed study will describe the patterns and determinants of maternal diet and nutritional status in mid to late pregnancy among HIV-infected women in Lilongwe, Malawi, and relate their diet and nutritional status to birth outcomes, including low birth weight, small-size-for-gestational age at birth (SGA), and preterm births. The study will also evaluate the contribution of a World Food Program food ration given to HIV-infected women, assessing how the food supplement was consumed, whether it enhanced maternal dietary intake and diet quality, and whether it affected nutritional status and birth outcomes. The study will use data from about 1,400 participants in the Breastfeeding, Antiretroviral, and Nutrition (BAN) Study, an ongoing clinical trial to evaluate antiretroviral and nutrition interventions to reduce mother-to-child transmission of HIV during breast-feeding in Lilongwe, Malawi. This work will contribute to our knowledge of factors that affect the health of HIV-infected women and their newborn infants in a resource-constrained setting, and thus inform strategies for nutrition counseling and interventions designed to improve maternal health, survival and birth outcomes. PROPOSAL NARRATIVE The proposed study will describe the patterns and determinants of maternal diet and nutritional status in mid to late pregnancy among HIV-infected women in Lilongwe, Malawi, and relate their diet and nutritional status to birth outcomes, including low birth weight, small-size-for-gestational age at birth (SGA), and preterm births. The study will also evaluate the contribution of a World Food Program food ration given to HIV-infected women, assessing how the food supplement was consumed, whether it enhanced maternal dietary intake and diet quality, and whether it affected nutritional status and birth outcomes.

描述（由申请人提供）：在撒哈拉以南非洲地区，估计有 1,350 万育龄妇女感染艾滋病毒。当艾滋病毒感染者怀孕时，她们不仅要面对怀孕时通常的生理和营养需求，还要面临感染带来的额外需求。在粮食不安全程度高、孕产妇工作负担重的环境中，妇女可能无法消费足够的优质食品来满足这些日益增加的营养需求，从而使她们面临更大的健康状况不佳、疾病进展更快和贫困风险增加的风险。出生结果。大多数与妊娠期艾滋病毒相关的研究都集中在减少艾滋病毒母婴传播 (MTCT) 的抗逆转录病毒策略上。人们很少关注孕产妇健康和营养状况。拟议的研究将描述马拉维利隆圭感染艾滋病毒的妇女怀孕中后期的母亲饮食和营养状况的模式和决定因素，并将她们的饮食和营养状况与出生结果联系起来，包括低出生体重、小体型和出生体重。出生时妊娠年龄 (SGA) 和早产。该研究还将评估世界粮食计划署向艾滋病毒感染妇女提供的食品配给的贡献，评估食品补充剂的消耗方式、是否提高了母亲的饮食摄入量和饮食质量，以及是否影响营养状况和出生结果。该研究将使用来自母乳喂养、抗逆转录病毒和营养 (BAN) 研究的约 1,400 名参与者的数据，该研究是一项正在进行的临床试验，旨在评估抗逆转录病毒和营养干预措施，以减少马拉维利隆圭母乳喂养期间艾滋病毒的母婴传播。这项工作将有助于我们了解在资源有限的环境中影响艾滋病毒感染妇女及其新生儿健康的因素，从而为旨在改善孕产妇健康、生存和出生结果的营养咨询和干预策略提供信息。提案叙述 拟议的研究将描述马拉维利隆圭感染艾滋病毒的妇女怀孕中后期的母亲饮食和营养状况的模式和决定因素，并将她们的饮食和营养状况与出生结果联系起来，包括低出生体重、小体型出生时妊娠年龄 (SGA) 和早产。该研究还将评估世界粮食计划署向艾滋病毒感染妇女提供的食品配给的贡献，评估食品补充剂的消耗方式、是否提高了母亲的饮食摄入量和饮食质量，以及是否影响营养状况和出生结果。