College of Medicine Phoenix Campus Vivarium Phase I Construction

医学院凤凰城校区动物园一期建设

• 批准号: 7898290
• 负责人: DAVID G BESSELSEN
• 金额: $ 1499.6万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7898290
• 关键词: Animal Experimentation; Animals; Area; Arizona; Award; Beds; Behavioral; Behavioral Assay; Blood; Breeding; Certification; Cities; Containment; Decontamination; Equipment; Euthanasia; Faculty; Food; Future; Health Sciences; Housing; Image; Injection of therapeutic agent; Laboratories; Laboratory Animals; Laboratory Research; Measurement; Medicine; Mus; Occupations; Operative Surgical Procedures; Osmosis; Phase; Physiological; Procedures; Production; Quarantine; Rattus; Recruitment Activity; Recycling; Research; Research Support; Rodent; Silver; Site; System; Telemetry; Tissue Banks; Transgenic Mice; Universities; Water; animal care; climate change; college; exhaust; in vivo; irradiation; medical schools; meetings; metropolitan; operation; science education; segregation

DESCRIPTION (provided by applicant): The University of Arizona College of Medicine - Phoenix in Partnership with Arizona State University (COM-P) recruited its first new faculty to the Phoenix Biomedical Campus in 2006, and currently has 22 faculty with research laboratories in the Arizona Biomedical Collaborative 1 (ABC 1). Animal research by these faculty is currently conducted at various AAALAC-approved vivarium facilities throughout the Phoenix metropolitan area. The specific aim of the present proposal is to support construction of a 12,100 DGSF vivarium on campus to meet existing and future scientific needs. This represents Phase One of a larger vivarium project currently planned for the Phoenix Biomedical Campus along with construction of the Health Sciences Education Building and the ABC 2 research building. The COM-P Phase One Vivarium will include animal holding rooms with a total capacity of 4,158 mouse cages and 1,200 rat cages for rodent housing. Rooms will be provided for breeding of transgenic mice lines, specialized behavioral assays of rats and mice, animal biosafety level 2 (ABSL2) procedures in mice, quarantine of rats and mice, and segregation of rodents returning to the vivarium from laboratories. Specialized suites are included for behavioral analyses, ABSL2 containment and decontamination, and small animal imaging and irradiation. In addition, areas will be dedicated to clean and dirty cage, food and bedding storage; animal receiving; euthanasia and veterinary procedures; surgical facilities, and procedure rooms for physiological measurement, telemetry, injections, blood and tissue collection, and other in vivo procedures. The vivarium will house rodents in Innovive(R) individually ventilated, disposable (recyclable) caging systems. In addition, locker rooms with restrooms and showers, a staff room and office are provided. Fixed, major equipment requested includes: two Class 2, Type B2 fully exhausted biosafety cabinets, seven Class 2, Type A2 biosafety cabinets, an autoclave, examination lamps, and a reverse osmosis Hydropak water pouch production system. In accordance with the Initiative on Climate Change, signed by the participating University Presidents, this project will pursue LEED Silver certification with sustainability concepts, including recycling, energy efficiency, reduced water use and sustainable site and open space plans. The COM-P Phase One Vivarium will provide much needed facilities in support of existing PHS research at a new and rapidly growing medical college located in the fifth largest U.S. city. Timely award and construction of the project will create or retain 126 jobs, with ongoing operations of the facility creating or retaining 18 jobs. The best and only way to assure optimal standards of experimental animal care required for our PHS-supported research efforts is to construct this dedicated laboratory animal vivarium serving the Phoenix Biomedical Campus.

描述（由申请人提供）： 亚利桑那大学医学院 - 菲尼克斯分校与亚利桑那州立大学 (COM-P) 合作，于 2006 年在菲尼克斯生物医学校区招募了第一批新教职人员，目前拥有 22 名教职员工，并在该校区设有研究实验室。亚利桑那州生物医学合作组织 1 (ABC 1)。这些教师目前在凤凰城大都市区的多个经 AAALAC 批准的动物饲养场设施中进行动物研究。本提案的具体目标是支持在校园内建设 12,100 个 DGSF 动物饲养场，以满足现有和未来的科学需求。这是凤凰城生物医学园区目前规划的大型动物饲养场项目的第一阶段，以及健康科学教育大楼和 ABC 2 研究大楼的建设。 COM-P 第一期动物园将包括动物饲养室，总容量为 4,158 个小鼠笼和 1,200 个用于啮齿动物饲养的大鼠笼。将提供用于转基因小鼠品系的繁殖、大鼠和小鼠的专门行为分析、小鼠动物生物安全2级（ABSL2）程序、大鼠和小鼠的检疫以及从实验室返回饲养场的啮齿动物的隔离的房间。包括用于行为分析、ABSL2 遏制和净化以及小动物成像和照射的专用套件。此外，还将专门设置一些区域来存放干净和肮脏的笼子、食物和床上用品；动物接收；安乐死和兽医程序；手术设施以及用于生理测量、遥测、注射、血液和组织采集以及其他体内程序的手术室。该动物园将把啮齿动物安置在 Innovive(R) 单独通风的一次性（可回收）笼养系统中。此外，还提供带卫生间和淋浴的更衣室、员工室和办公室。所需的固定主要设备包括：两个 2 级 B2 型完全排气生物安全柜、七个 2 级 A2 型生物安全柜、高压灭菌器、检查灯和反渗透 Hydropak 水袋生产系统。根据参与大学校长签署的气候变化倡议，该项目将寻求具有可持续性概念的 LEED 银级认证，包括回收、能源效率、减少用水以及可持续场地和开放空间计划。 COM-P 第一阶段动物园将提供急需的设施，以支持位于美国第五大城市的一所快速发展的新兴医学院的现有 PHS 研究。该项目的及时授予和建设将创造或保留 126 个就业岗位，该设施的持续运营将创造或保留 18 个就业岗位。确保我们 PHS 支持的研究工作所需的实验动物护理达到最佳标准的最佳且唯一的方法是建造这个为凤凰城生物医学园区服务的专用实验动物饲养场。

项目成果

Isolation and characterization of patient-derived CNS metastasis-associated stromal cell lines.

患者来源的中枢神经系统转移相关基质细胞系的分离和表征。

• 发表时间: 2019
• 影响因子: 8
• 作者: Tew, Ben Yi;Legendre, Christophe;Gooden, Gerald C;Johnson, Kyle N;Martinez, Rae Anne;Kiefer, Jeff;Bernstein, Mark;Glen, Jennifer;Butry, Loren;Hinek, Aleksander;Toms, Steven A;Salhia, Bodour
• 通讯作者: Salhia, Bodour