Individual Cognitive-Behavioral Psychotherapy for IED

IED 的个体认知行为心理治疗

• 批准号: 7147901
• 负责人: MICHAEL S MCCLOSKEY
• 金额: $ 14.79万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-08 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7147901
• 关键词: aggression; angers; behavior prediction; behavioral /social science research tag; clinical research; clinical trials; cognitive behavior therapy; compulsive behavior; emotions; face expression; human subject; human therapy evaluation; impulsive behavior; longitudinal human study; neural information processing; neuropsychology; patient oriented research; perception; psychological adaptation; psychosis; relaxation; social behavior; violence prevention

DESCRIPTION (provided by applicant): Intermittent Explosive Disorder (IED) is increasingly acknowledged as a common, potentially disabling psychiatric condition. Despite this, there are currently no empirically supported behavioral treatments for patients with IED. The purpose of the proposed study is to assess the short-term and long-term efficacy of a cognitive-behavioral treatment (CBT), previously found to be successful in treating dysfunctional anger, for treating IED. Secondary goals of the project are to (a) explore mechanisms involved in the successful treatment of IED, and (b) examine individual differences associated with treatment response. This request for a Patient-Oriented Mentored Scientist Award (K23) serves to cultivate the candidate's research acumen as it relates to randomized clinical trials, advanced biostatistical methodologies, and cognitive neuroscience. Ninety subjects meeting criteria for both current research and current DSM IED criteria will be randomly assigned to either 12 weeks of CBT or 12 weeks of a supportive psychotherapy control condition. Subjects will be assessed before and after therapy as well as at 6 month and 12 month follow-up. Primary outcome measures will assess aggressive behavior, anger, and the presence of an IED diagnosis at post-treatment, 6-month follow-up and 12-month follow-up. Social and emotional information processing will be evaluated as potential mechanism of change. Trait aggression will be assessed as a potential moderating variable.

描述（由申请人提供）：间歇性爆发性精神障碍（IED）越来越被认为是一种常见的、可能致残的精神疾病。尽管如此，目前还没有针对简易爆炸装置患者的经验支持的行为治疗。拟议研究的目的是评估认知行为疗法 (CBT) 治疗简易爆炸装置的短期和长期疗效，此前该疗法被发现可成功治疗功能失调性愤怒。该项目的次要目标是（a）探索成功治疗简易爆炸装置的机制，以及（b）检查与治疗反应相关的个体差异。申请以患者为导向的导师科学家奖（K23）旨在培养候选人的研究敏锐度，因为它涉及随机临床试验、先进的生物统计方法和认知神经科学。符合当前研究标准和当前 DSM IED 标准的 90 名受试者将被随机分配接受 12 周的 CBT 或 12 周的支持性心理治疗控制条件。受试者将在治疗前后以及 6 个月和 12 个月的随访时接受评估。主要结果指标将评估攻击行为、愤怒以及治疗后、6 个月随访和 12 个月随访时是否存在简易爆炸装置诊断。社会和情感信息处理将被评估为潜在的变化机制。攻击性特质将被评估为潜在的调节变量。