Adipocyte Biology Core E

脂肪细胞生物学核心 E

• 批准号: 7116102
• 负责人: Nada A. Abumrad
• 金额: $ 11.19万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7116102
• 关键词: adipocytes; adipose tissue; biomedical facility; clinical research; nutrition; obesity

Obesity, which is characterized by excess adipose tissue mass, is associated with metabolic abnormalities and systemic inflammation. The mechanism(s) responsible for this relationship is not completely known but likely involves the endocrine functions of adipose tissue. Adipose tissue produces a variety of bioactive substances (i.e. adipokines) with central or peripheral actions that regulate food intake and energy expenditure (1). In addition, plasma concentrations of some adipokines are associated with many features of the Metabolic Syndrome, such as insulin resistance, type 2 diabetes mellitus, dyslipidemia, and coronary artery disease (2). Accordingly, the number of investigators who are interested in the molecular biology and cellular physiology of adipocytes and adipose tissue is increasing. To address this growing interest at Washington University, we conducted a survey of our faculty regarding their interest and need for research services involving adipose tissue. In response to this survey, we propose an Adipocyte Biology Core (ABC), which is specifically tailored to meet the needs of CNRU investigators and faculty in basic and clinical departments who wish to conduct nutrition- or obesity- related adipose tissue research. These services do not overlap with those provided by other cores, and services for adipose tissue cell sizing and macrophage content will be coordinated with the Histology Core of the Diabetes Research and Training Center to maximize efficiency and cost-effectiveness. The study of adipose tissue biology requires specific methods, equipment and expertise that are difficult to assemble by individual investigators and present a barrier to those who are new to this field. Therefore, the overall objective of the ABC is to provide CNRU researchers with access to the training, expertise, and facilities needed for comprehensive study of adipose tissue.

肥胖的特点是脂肪组织量过多，与代谢异常有关 和全身炎症。负责这种关系的机制尚不完全清楚，但 可能涉及脂肪组织的内分泌功能。脂肪组织产生多种生物活性物质 具有调节食物摄入和能量的中枢或外周作用的物质（即脂肪因子） 支出（1）。此外，一些脂肪因子的血浆浓度与许多特征相关 代谢综合征，如胰岛素抵抗、2 型糖尿病、血脂异常和冠心病 动脉疾病（2）。因此，对分子生物学感兴趣的研究人员数量 脂肪细胞和脂肪组织的细胞生理学正在增加。为了解决这种日益增长的兴趣 华盛顿大学，我们对我们的教师进行了一项调查，了解他们对研究的兴趣和需求 涉及脂肪组织的服务。为了回应这项调查，我们提出了脂肪细胞生物学核心 (ABC)，专为满足 CNRU 研究人员和教师在基础方面的需求而定制 以及希望进行营养或肥胖相关脂肪组织研究的临床部门。 这些服务与其他核心提供的服务以及脂肪组织细胞服务不重叠 大小和巨噬细胞含量将与糖尿病研究的组织学核心相协调 培训中心最大限度地提高效率和成本效益。脂肪组织生物学的研究需要 个别调查人员难以收集的具体方法、设备和专业知识， 对这个领域的新手来说是一个障碍。因此，ABC 的总体目标是 为 CNRU 研究人员提供所需的培训、专业知识和设施 脂肪组织的综合研究。