Pooling of Prospective Studies of Diet and Cancer

饮食与癌症前瞻性研究的汇集

• 批准号: 7191215
• 负责人: STEPHANIE A SMITH-WARNER
• 金额: $ 36.8万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7191215
• 关键词: Age; Alcohol consumption; Alcohols; All-Trans-Retinol; Animals; Ascorbic Acid; Asia; Attenuated; Australia; Body mass index; Calcium; Calcium Milk; Carotenoids; Clinical; Cohort Studies; Communication; Consumption; Country; Data; Diet; Dietary Assessment; Dietary Factors; Elderly; Estrogen Receptor Status; Estrogen receptor negative; Ethnic Origin; Europe; Fatty Acids; Fatty acid glycerol esters; Female; Fishes; Folate; Follow-Up Studies; Food; Gleason Grade for Prostate Cancer; Glioma; Habits; Heterogeneity; Incidence; Individual; Intake; Malignant Neoplasms; Malignant neoplasm of prostate; Marines; Meat; Meta-Analysis; Methods; Modeling; Multivitamin; North America; Numbers; Omega-3 Fatty Acids; Outcome; Participant; Population; Process; Prospective Studies; Publication Bias; Publications; Publishing; Range; Rate; Research Design; Research Personnel; Risk; Risk Factors; Series; Smoker; Smoking; Smoking Status; Source; Staging; Tomatoes; Vegetables; Vitamin A; Vitamin D; Vitamin E; Woman; cancer risk; cancer site; cohort; cost; diet and cancer; follow-up; fruits and vegetables; inclusion criteria; insight; male; malignant breast neoplasm; men; older men; prospective; sex

We propose to examine the association between dietary factors and risk of advanced prostate cancer, estrogen receptor negative breast cancer, and gliomas in the Pooling Project of Prospective Studies of Diet and Cancer (Pooling Project), a consortium of 27 prospective cohort studies. Each study met the following inclusion criteria: used a prospective study design, assessed usual diet using a validated dietary assessment method, and met the minimum number of incident cases. The studies were conducted in North America (n=18), Europe (n=6), Asia (n=2), and Australia (n=1) with 834,339 male (n=14 studies) and 1,364,231 female (n=23 studies) participants. During follow-up of these studies, 5,503 advanced prostate cancer (which will be analyzed separately as either stage C and D or as Gleason score >7), 5,484 estrogen receptor negative breast cancer, and 2,516 glioma cases were identified. For advanced prostate cancer, associations with dairy foods, calcium, vitamin D, meat, fat, fruits, vegetables, vitamin E, and body mass index will be examined. For estrogen receptor negative breast cancer, analyses will evaluate fruits, vegetables, and alcohol. For gliomas, associations with vitamins D, C, and E, processed meat, fish, fat, fruits, vegetables, and alcohol will be analyzed. Expansion of the Pooling Project to these cancers with intermediate or low incidence rates will take advantage of the statistical power of this project. In addition, because individual studies will not be required to have published on the specific associations being examined, publication bias will be avoided in these analyses. We will recode the primary data from each study using a standardized approach across studies so that the exposures, covariates, and outcomes will be defined and modeled consistently across studies. This standardized approach will reduce potential sources of between-studies heterogeneity. Analyses will also evaluate whether associationsare modified by other risk factors including sex, ethnicity, age, smoking habits, and other dietary factors to identify potential high-risk groups that may not otherwise be identified in smaller studies. Because the Pooling Project includes populations with different diets, the range of intakes that can be examined will be wider than in individual studies, further increasing the statistical power of the study. The annual meetings, and frequent communication among investigators, will facilitate the analyses and interpretation of the findings. These analyses will take full advantage of extensive data already collected to provide powerful insights into the relation between diet and the risk of advanced prostate cancer, estrogen receptor negative breast cancer, and gliomas, cancer sites that have been examined in few prospective studies. This project provides a highly cost-effective approach to evaluate these pressing issues in a detailed, standardized manner, to yield robust findings that have immediate clinical and public relevance.

我们建议检查饮食因素与晚期前列腺癌风险之间的关联， 饮食前瞻性研究的汇总项目中的雌激素受体阴性乳腺癌和胶质瘤 和癌症（Pool Project），这是27个前瞻性队列研究的财团。每个研究都符合以下 纳入标准：使用前瞻性研究设计，使用经过验证的饮食评估评估了通常的饮食 方法，并满足事件案例的最少数量。研究是在北美进行的 （n = 18），欧洲（n = 6），亚洲（n = 2）和澳大利亚（n = 1），男性为834,339（n = 14个研究）和1,364,231 女性（n = 23个研究）参与者。在这些研究的随访期间，有5,503个晚期前列腺癌（这 将分别分析为C和D期或Gleason评分> 7），5,484个雌激素受体 鉴定出阴性乳腺癌和2,516例神经胶质瘤病例。对于晚期前列腺癌，关联 乳制品，钙，维生素D，肉，脂肪，水果，蔬菜，维生素E和体重指数将是 检查。对于雌激素受体阴性乳腺癌，分析将评估水果，蔬菜和 酒精。对于神经胶质瘤，与维生素D，C和E相关，加工的肉，鱼，脂肪，水果，蔬菜， 将分析酒精。将集合项目扩展到中间或低的癌症 发病率将利用该项目的统计能力。另外，因为个人 不需要研究就正在研究的具体关联，出版偏见发表研究 这些分析将避免。我们将使用标准化的每个研究中的主要数据进行回顾 在整个研究中的方法，以便定义和建模暴露，协变量和结果 一贯跨研究。这种标准化方法将减少潜在的研究来源 异质性。分析还将评估是否通过其他风险因素进行修改，包括 性别，种族，年龄，吸烟习惯和其他饮食因素，以识别可能的高风险群体 否则在较小的研究中无法识别。因为汇总项目包括与 不同的饮食，可以检查的摄入量将比单个研究更宽，进一步 增加研究的统计能力。年度会议，以及频繁的沟通 研究人员将促进对发现的分析和解释。这些分析将充满 已经收集了广泛数据的优势，可以为饮食与饮食之间的关系提供强有力的见解 晚期前列腺癌，雌激素受体阴性乳腺癌和神经胶质瘤的风险，癌症部位 在少数前瞻性研究中已经检查了这些。该项目提供了一种高度成本效益的方法 以详细的标准化方式评估这些紧迫问题，以产生具有的强大发现 立即临床和公众相关性。