BIOSTATISTICS

生物统计学

• 批准号: 7303278
• 负责人: paul frankel
• 金额: $ 18.32万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7303278
• 关键词: Antibodies; Basic Science; Biometry; Biostatistics Core; Clinical; Clinical Research; Clinical Research Associate; Clinical Trials; Collaborations; Commit; Compatible; Computer software; Data; Data Collection; Development; Ensure; Image; Immunotherapy; Investigation; Leadership; Measures; Methods; Monitor; Peer Review; Principal Investigator; Process; Program Research Project Grants; Publications; Radiation; Research; Research Design; Research Personnel; Resources; Role; SAS; Safety; Sample Size; Solid Neoplasm; Testing; Translational Research; Writing; abstracting; experience; innovation; medical specialties; programs; quality assurance; response

Core E core Director Frankel, Paul Principal investigator: Raubitschek, Andrew DESCRIPTION: The Biostatistics Core serves as a centralized resource to the investigators of the Antibody Targeted Radiation and Immunotherapy for the Treatment of Solid Tumors Program Project Grant (PPG), providing Diostatistical expertise and clinical research management resources to all projects. The Biostatistics Core includes two Senior Biostatisticians (one is the Core Director), 1 Staff Biostatistician, a Quality Assurance Clinical Research Associate, and a Clinical Research Associate. The Biostatistics Core provides study design, sample size projections, safety monitoring, case form development, data collection, data quality assurance, statistical programming, summary and analysis of study results, and collaboration in writing abstracts and peer-review publications. Statistical analyses are performed using SAS, S-PLUS, R software packages, and specialty software. The Biostatistics Core ensures that the proposed research hypothesis will be measured, tested, and interpreted, independent of whether the data comes from basic science, translational or mmunologic studies, imaging, or clinical trials. The Biostatistics Core will also continue to provide nfrastructure for the management and integration of both existing and newly collected data through consistent and compatible data handling, which is particularly important given the large amount of data collected and processed as part of the Imaging Response Assessment Team (IRAT), the IRAT workstation that will employed for this PPG, and the important cross study analysis that will be conducted. The Core will continue to have an integral role in the scientific development, execution and analysis of all projects in the PPG, including clinical trials. Core investigators have extensive experience in quantitative methods for biomedical applications, including clinical, basic and translational science studies. The Core is committed to continue its leadership role in the scientific integrity of the PPG investigations, to participating in regular project and program meetings, and to providing rigorous and innovative input on all quantitative matters arising in the projects. Their contribution to each project promotes interdisciplinary interactions and innovative hypotheses for exploration. The Biostatistics Core has been involved in study design for each specific aims of the current proposal, and will continue to be a critical component to successful conduct of the PPG.

Core E core 主任 Frankel, Paul 首席研究员：Raubitschek, Andrew 描述： 生物统计学核心作为抗体靶向研究人员的集中资源 用于治疗实体瘤的放射和免疫疗法计划项目拨款 (PPG)，提供 所有项目的统计专业知识和临床研究管理资源。生物统计学核心 包括两名高级生物统计学家（一名是核心主任）、一名生物统计学家、一名质量保证员 临床研究员和临床研究员。生物统计学核心提供研究设计、 样本量预测、安全监测、案例表格开发、数据收集、数据质量保证、 统计编程、研究结果的总结和分析以及撰写摘要和分析的协作 同行评审出版物。使用 SAS、S-PLUS、R 软件包和 专业软件。生物统计学核心确保所提出的研究假设得到测量， 测试和解释，独立于数据是否来自基础科学、转化或 免疫学研究、成像或临床试验。生物统计核心还将继续提供 通过以下方式管理和集成现有数据和新收集的数据的基础设施 一致且兼容的数据处理，考虑到大量数据，这一点尤为重要 作为影像反应评估小组 (IRAT)、IRAT 工作站的一部分收集和处理 将用于此 PPG，以及将进行的重要交叉研究分析。核心将 继续在所有项目的科学开发、执行和分析中发挥不可或缺的作用 PPG，包括临床试验。核心研究者在定量方法方面拥有丰富的经验 生物医学应用，包括临床、基础和转化科学研究。核心致力于 继续在 PPG 调查的科学诚信方面发挥领导作用，定期参加 项目和计划会议，并就所有定量问题提供严格和创新的投入 项目中产生的。他们对每个项目的贡献促进了跨学科互动和 探索的创新假设。生物统计学核心参与了每个项目的研究设计 当前提案的具体目标，并将继续成为成功开展 PPG。