Characterization of Carotid Artery Flow

颈动脉血流的表征

基本信息

批准号：
7279210
负责人：
TAMARA N FITZGERALD
金额：
$ 5.2万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-08-07 至 2008-07-01
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7279210
关键词：
Address Advocate Affect Angioplasty Apoptosis Blood Circulation Carotid Arteries Carotid Endarterectomy Carotid Stenosis Cell Proliferation Characteristics Clinic Clinical Condition Conflict (Psychology)Data Disease Disease Outcome Distal Doppler Ultrasound Endarterectomy Fellowship Fourier Transform Frequencies Harvest Histologic Histology Human Hyperplasia Image In Vitro Individual Injury Intervention Invasive Laboratories Liquid substance Literature Magnetic Resonance Imaging Measures Methods Modality Modeling Morbidity - disease rate Names Operative Surgical Procedures Oryctolagus cuniculus Patients Pattern Personal Satisfaction Play Procedures Process Property Radiation Reporting Risk Role Smooth Muscle Myocytes Source Stenosis Stents Stroke Techniques Treatment Efficacy Treatment outcome Validation Work base computerized data processing day hemodynamics human subject in vivo monolayer novel research study response restenosis shear stress two-dimensional vector

项目摘要

DESCRIPTION (provided by applicant): Carotid angioplasty is a rapidly evolving endovascular treatment for carotid stenosis, and advocates predict that is will replace surgical endarterectomy. The hemodynamic changes following angioplasty (whether the flow remains simple or laminar, or becomes a three-dimensional complicated flow with a non-trivial spectrum of frequencies and regions of recirculation) are not well described. Flow characteristics may prove to be predictive of disease outcome and treatment efficacy after carotid endarterectomy or angioplasty. Therefore, we propose that characterizing flow according to its laminar or complicated properties will provide a more effective means to predict arterial changes seen at the histological level and differences in restenosis and stroke risk. MRI provides a non-invasive and radiation-free method of obtaining accurate arterial information, making it an ideal modality to study arterial flow in both an experimental and clinical setting. Ultimately this technique can be investigated in a clinical setting to study flow characteristics in the human carotid artery before and after angioplasty or endarterectomy, and used to predict treatment outcome on an individual patient basis.

描述（由申请人提供）：颈动脉血管成形术是一种快速发展的颈动脉狭窄血管内治疗方法，拥护者预测它将取代外科动脉内膜切除术。血管成形术后的血流动力学变化（血流是否保持简单或层流，或成为具有非平凡的频率谱和再循环区域的三维复杂血流）尚未得到很好的描述。血流特征可能被证明可以预测颈动脉内膜切除术或血管成形术后的疾病结果和治疗效果。因此，我们建议根据其层流或复杂特性来表征血流将提供更有效的方法来预测组织学水平上的动脉变化以及再狭窄和中风风险的差异。 MRI 提供了一种非侵入性、无辐射的方法来获取准确的动脉信息，使其成为在实验和临床环境中研究动脉血流的理想方式。最终，这项技术可以在临床环境中进行研究，以研究血管成形术或动脉内膜切除术前后人类颈动脉的血流特征，并用于预测个体患者的治疗结果。