Advanced Research Training in Transplantation Immunobiology

移植免疫生物学高级研究培训

• 批准号: 7280768
• 负责人: THOMAS C PEARSON
• 金额: $ 16.83万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7280768
• 关键词: Immunobiology; Research Training; Transplantation

DESCRIPTION (provided by applicant): This training grant has been created to increase excellent training of individuals in translational research who will pursue careers in basic and applied immunobiology of transplantation. Transplantation, now recognized as the optimal therapy for patients with many types of end-stage organ failure, is a highly specialized field in which immunology plays a crucial role. Future progress in organ transplantation will require the development of new classes of immunosuppressive agents associated with dramatically less toxicity but equal or greater potency than currently available regimens and the development of accurate methods of immune monitoring to assess immune responsiveness of graft recipients so that individualized immunosuppression regimens can be effectively provided. However, the field of transplantation can only fully advance if a more thorough understanding of the immune response to alloantigens, as well as to the antigens expressed by pathogenic micro-organisms and neoplastic cells, is achieved. At present, short term outcomes are improving, but consistent long term successful outcomes in transplantation are still beyond our reach. Given our current limited knowledge with respect to immunological processes in transplantation, attaining significant improvements in outcome will require a series of carefully structured studies in rodents, non-human primates, and ultimately in humans. To meet the demand to improve this field as quickly as possible, it will be necessary to recruit and retain substantially more investigators possessing both interest and expertise into the field of transplantation immunobiology, as the number of investigators in this field are currently under-represented, relative to those in other high demand fields such as oncology and cardiovascular disease research. This proposed training program seeks to recruit and rigorously train highly qualified and motivated pre-doctoral and post-doctoral candidates in translational research in transplantation immunology. It is hoped that they will pursue careers in the field of transplantation immunobiology, producing scientific advances that can be translated into improved clinical practice; thus, significantly improving the length and quality of life of transplant patients in the near future.

描述（由申请人提供）：已创建了这项培训赠款，以增加对转化研究中个人的出色培训，这些培训将从事基本和应用的移植免疫生物学的职业。移植现在被认为是许多类型的终末期器官衰竭患者的最佳治疗，是一个高度专业的领域，免疫学在其中起着至关重要的作用。器官移植中未来的进步将需要与当前可用的方案相关的新型免疫抑制剂，但与当前可用的方案相比，相等或更大的效力以及准确的免疫监测方法的发展，以评估嫁接受体的免疫反应能力，从而可以有效地提供个性化的免疫治疗方案。但是，只有在对同种抗原的免疫反应以及对病原性微生物和肿瘤细胞表达的抗原方面的免疫反应以及对抗原的免疫反应更加彻底的了解，才能完全前进。目前，短期结局正在改善，但是长期移植的长期成功结果仍然超出了我们的影响力。鉴于我们目前关于移植中免疫学过程的知识有限，因此在啮齿动物，非人类灵长类动物以及最终在人类中进行一系列精心结构的研究，将需要一系列仔细的结构化研究。为了满足尽快改善该领域的需求，有必要招募并保留更多的研究人员，这些调查人员在移植免疫生物学领域中既具有兴趣和专业知识，又有该领域的研究人员的数量目前代表性不足，相对于其他高需求领域（例如肿瘤学和心血管疾病研究）。该拟议的培训计划旨在招募和严格培训移植免疫学转化研究的高度合格和积极的博士前和动机后候选者。希望他们能在移植免疫生物学领域从事职业，从而产生科学进步，可以将其转化为改善的临床实践。因此，在不久的将来，显着改善了移植患者的寿命长度和质量。